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PHR1476 Supelco

Diethyl Phthalate

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: Diethyl phthalate

  • CAS Number 84-66-2

  • Linear Formula C6H4-1,2-(CO2C2H5)2

  • Molecular Weight 222.24

  •  Beilstein/REAXYS Number 1912500

  •  EC Number 201-550-6

  •  MDL number MFCD00009111

  •  PubChem Substance ID 329823404

  •  NACRES NA.24

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, C-D, Food & Beverage Standards, Food Contact Materials,
Quality Level   300
grade   certified reference material
  pharmaceutical secondary standard
vapor density   7.66 (vs air)
vapor pressure   1 mmHg ( 100 °C)
autoignition temp.   854 °F
expl. lim.   0.75 %, 187 °F
packaging   pkg of 1 g
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
refractive index   n20/D 1.502 (lit.)
bp   298-299 °C (lit.)
mp   −3 °C (lit.)
density   1.12 g/mL at 25 °C (lit.)
Featured Industry   Pharmaceutical (small molecule)
format   neat
pharmacopeia traceability   traceable to PhEur D1410000
  traceable to USP 1193505
SMILES string   CCOC(=O)c1ccccc1C(=O)OCC
InChI   1S/C12H14O4/c1-3-15-11(13)9-7-5-6-8-10(9)12(14)16-4-2/h5-8H,3-4H2,1-2H3
InChI key   FLKPEMZONWLCSK-UHFFFAOYSA-N

Description

General description

Diethyl Phthalate is a phthalic acid ester, commonly synthesized by the condensation of the carboxy groups of phthalic acid with methanol.. It is used as a solvent for fragrance in cosmetic formulations and personal care products.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Diethyl Phthalate may be used as a pharmaceutical reference standard for the determination of the analyte in cosmetic products, pharmaceutical formulations and dietary supplements by chromatography.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA3024 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

RIDADR 
UN 3082 9 / PGIII
WGK Germany 
WGK 2
Flash Point(F) 
338.0 °F - closed cup
Flash Point(C) 
170 °C - closed cup
Protocols & Articles

Articles

GC Analysis of Phthalate Esters on Equity®-5

From our library of Articles, Sigma-Aldrich presents GC Analysis of Phthalate Esters on Equity®-5
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Purification

GC Analysis of Semivolatiles in Drinking Water on a 5% Phenyl Column after SPE using ENVI™-18 DSK

From our library of Articles, Sigma-Aldrich presents GC Analysis of Semivolatiles in Drinking Water on a 5% Phenyl Column after SPE using ENVI™-18 DSK
Keywords: Chromatography, Gas chromatography, Mass spectrometry, Purification, Sample preparations, Solid phase extractions

GC Analysis of Semivolatiles in Water on a 5% Phenyl Column after SPME using 7 μm PDMS

From our library of Articles, Sigma-Aldrich presents GC Analysis of Semivolatiles in Water on a 5% Phenyl Column after SPME using 7 μm PDMS
Keywords: Chromatography, Environmental, Gas chromatography, Mass spectrometry, Purification, Size-exclusion chromatography, Solid phase microextractions

Qualification of Sunscreens Using Certified Reference Materials

Absorbing the sun’s rays helps the body create an important nutrient, Vitamin D, for immune system function and proper bone density. Exposing oneself to sunlight can have positive effects - setting t...
Keywords: Absorption, Cancer, Pharmaceutical, Vitamins

US EPA Method 525.2: GC Analysis of Semivolatiles on SLB®-5ms, Fast GC Analysis

From our library of Articles, Sigma-Aldrich presents US EPA Method 525.2: GC Analysis of Semivolatiles on SLB®-5ms, Fast GC Analysis
Keywords: Chromatography, Gas chromatography, Purification

US EPA Method 525.2: GC Analysis of Semivolatiles on SLB®-5ms

From our library of Articles, Sigma-Aldrich presents US EPA Method 525.2: GC Analysis of Semivolatiles on SLB®-5ms
Keywords: Chromatography, Gas chromatography, Purification

US EPA Method 625: GC Analysis of Semivolatiles on SLB®-5ms

From our library of Articles, Sigma-Aldrich presents US EPA Method 625: GC Analysis of Semivolatiles on SLB®-5ms
Keywords: Chromatography, Gas chromatography, Purification

US EPA Method 8270: GC Analysis of Semivolatiles on Equity®-5

From our library of Articles, Sigma-Aldrich presents US EPA Method 8270: GC Analysis of Semivolatiles on Equity®-5
Keywords: Chromatography, Gas chromatography, Mass selective detector, Purification

US EPA Method 8270: GC Analysis of Semivolatiles on SLB-5ms (20 m x 0.18 mm I.D., 0.36 μm), Fast GC Analysis

From our library of Articles, Sigma-Aldrich presents US EPA Method 8270: GC Analysis of Semivolatiles on SLB-5ms (20 m x 0.18 mm I.D., 0.36 μm), Fast GC Analysis
Keywords: Chromatography, Gas chromatography, Purification

US EPA Method 8270: GC Analysis of Semivolatiles on SLB®-5ms (20 m x 0.18 mm I.D., 0.18 μm), Fast GC Analysis

From our library of Articles, Sigma-Aldrich presents US EPA Method 8270: GC Analysis of Semivolatiles on SLB®-5ms (20 m x 0.18 mm I.D., 0.18 μm), Fast GC Analysis
Keywords: Chromatography, Gas chromatography, Purification, Size-exclusion chromatography

US EPA Method 8270: GC Analysis of Semivolatiles on SLB®-5ms (20 m x 0.18 mm I.D., 0.36 μm), 28 °C/min Oven Ramp, Fast GC Analysis

From our library of Articles, Sigma-Aldrich presents US EPA Method 8270: GC Analysis of Semivolatiles on SLB®-5ms (20 m x 0.18 mm I.D., 0.36 μm), 28 °C/min Oven Ramp, Fast GC Analysis
Keywords: Chromatography, Gas chromatography, Purification

US EPA Method 8270: GC Analysis of Semivolatiles on SLB®-5ms (30 m x 0.25 mm I.D., 0.50 μm)

From our library of Articles, Sigma-Aldrich presents US EPA Method 8270: GC Analysis of Semivolatiles on SLB®-5ms (30 m x 0.25 mm I.D., 0.50 μm)
Keywords: Chromatography, Gas chromatography, Purification

US EPA Method 8270: GC Analysis of Semivolatiles on SLB®-5ms, 350 °C Final Oven Temp.

From our library of Articles, Sigma-Aldrich presents US EPA Method 8270: GC Analysis of Semivolatiles on SLB®-5ms, 350 °C Final Oven Temp.
Keywords: Chromatography, Gas chromatography

US EPA Method 8270: GC Analysis of Semivolatiles on SLB®-5ms

From our library of Articles, Sigma-Aldrich presents US EPA Method 8270: GC Analysis of Semivolatiles on SLB®-5ms
Keywords: Chromatography, Gas chromatography, Purification

US EPA Method OLM04.2 SVOA: GC Analysis of Semivolatiles on SLB®-5ms

From our library of Articles, Sigma-Aldrich presents US EPA Method OLM04.2 SVOA: GC Analysis of Semivolatiles on SLB®-5ms
Keywords: Chromatography, Gas chromatography, Purification

Peer-Reviewed Papers
15

References

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