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PHR1549 Supelco

1,4-Dioxane

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: 1,4-Dioxane, Diethylene oxide, Dioxane

  • CAS Number 123-91-1

  • Empirical Formula (Hill Notation) C4H8O2

  • Molecular Weight 88.11

  •  Beilstein/REAXYS Number 102551

  •  EC Number 204-661-8

  •  MDL number MFCD00006571

  •  PubChem Substance ID 329823458

  •  NACRES NA.24

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, C-D, Food & Beverage Standards, Food Contact Materials,
Quality Level   300
grade   certified reference material
  pharmaceutical secondary standard
vapor density   3 (vs air)
vapor pressure   27 mmHg ( 20 °C)
  40 mmHg ( 25 °C)
autoignition temp.   356 °F
expl. lim.   22 %
packaging   ampule of 3x1.2 mL each
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
refractive index   n20/D 1.422 (lit.)
bp   100-102 °C (lit.)
mp   10-12 °C (lit.)
density   1.034 g/mL at 25 °C (lit.)
Featured Industry   Pharmaceutical (small molecule)
format   neat
pharmacopeia traceability   traceable to USP 1601521
SMILES string   C1COCCO1
InChI   1S/C4H8O2/c1-2-6-4-3-5-1/h1-4H2
InChI key   RYHBNJHYFVUHQT-UHFFFAOYSA-N

Description

General description

1,4-Dioxane belongs to the class of volatile organic compounds (VOCs).
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

1,4-Dioxane may be used as a pharmaceutical reference standard for the determination of the analyte in bulk pharmaceuticals, and cosmetic raw materials and finished products by chromatography.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC0289 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Target organs 
Respiratory system
Supplemental Hazard Statements 
EUH019 - EUH066
RIDADR 
UN1165 - class 3 - PG 2 - Dioxane
WGK Germany 
WGK 2
Flash Point(F) 
53.6 °F - closed cup
Flash Point(C) 
12 °C - closed cup
Protocols & Articles

Articles

GC Analysis of Industrial Solvents on Equity®-1

From our library of Articles, Sigma-Aldrich presents GC Analysis of Industrial Solvents on Equity®-1
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Purification, Size-exclusion chromatography

GC Analysis of Residual Solvents on SPB®-624 after SPME using 100 μm PDMS Fiber

From our library of Articles, Sigma-Aldrich presents GC Analysis of Residual Solvents on SPB®-624 after SPME using 100 μm PDMS Fiber
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Pharmaceutical, Purification, Sample preparations, Solid phase microextractions

US EPA Method 8270 (Appendix IX): GC Analysis of Semivolatiles on Equity®-5 (30 m x 0.25 mm I.D., 0.50 μm)

From our library of Articles, Sigma-Aldrich presents US EPA Method 8270 (Appendix IX): GC Analysis of Semivolatiles on Equity®-5 (30 m x 0.25 mm I.D., 0.50 μm)
Keywords: Chromatography, Gas chromatography, Mass selective detector, Purification

Peer-Reviewed Papers
15

References

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