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Oxymetazoline Hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: 2-(3-Hydroxy-2,6-dimethyl-4-t-butylbenzyl)-2-imidazoline hydrochloride, Oxymetazoline hydrochloride

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, K-O, Pharmaceutical Secondary Standards, Pharmacopeia & Metrological Institutes Standards More...
grade   certified reference material
  pharmaceutical secondary standard
InChI Key   BEEDODBODQVSIM-UHFFFAOYSA-N
packaging   ampule of 500 mg
Featured Industry   Pharmaceutical (small molecule)
format   neat
pharmacopeia traceability   traceable to PhEur O0290000
  traceable to USP 1486004

Description

General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Oxymetazoline hydrochloride belongs to the category of non-selective adrenergic drugs commonly used as eye and nose drops.

Application

Oxymetazoline hydrochloride may be used as a pharmaceutical secondary standard for the determination of the analyte in pharmaceutical formulations using spectrophotometric technique.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Oxymetazoline hydrochloride is a partial α2A-adrenoceptor agonist; agonist at 5-HT1A, 5-HT1B, and 5-HT1D serotonin receptors. It is a mixed agonist-antagonist at 5-HT1C serotonin receptors.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB5024 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGI
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Oxymetazoline Hydrochloride Identification Test B using silica gel G TLC plates

Oxymetazoline is an adrenergic alpha-agonists, used as a vasoconstrictor to relieve nasal congestion.
Dr Sanjay Poman
Merck KGaA, Darmstadt, Germany,Merck Life Science Application Centre (GAC) Mumbai, India
Keywords: Solvents, Thin layer chromatography

Peer-Reviewed Papers
15

References

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