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PHR1578 Supelco

Trolamine

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: 2,2′,2′′-Nitrilotriethanol, Triethanolamine, Tris(2-hydroxyethyl)amine

  • CAS Number 102-71-6

  • Linear Formula (HOCH2CH2)3N

  • Molecular Weight 149.19

  •  Beilstein/REAXYS Number 1699263

  •  EC Number 203-049-8

  •  MDL number MFCD00002855

  •  PubChem Substance ID 329823486

  •  NACRES NA.24

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, Chinese Food Contact Materials Regulation GB 9685 2016, Food & Beverage Standards, Food Contact Materials,
Quality Level   300
grade   certified reference material
  pharmaceutical secondary standard
vapor density   5.14 (vs air)
vapor pressure   0.01 mmHg ( 20 °C)
autoignition temp.   600 °F
expl. lim.   8.5 %
packaging   ampule of 5 mL
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
refractive index   n20/D 1.485 (lit.)
useful pH range   7.3 - 8.3
pKa (25 °C)   7.8
bp   190-193 °C/5 mmHg (lit.)
mp   17.9-21 °C (lit.)
density   1.124 g/mL at 25 °C (lit.)
Featured Industry   Pharmaceutical (small molecule)
format   neat
pharmacopeia traceability   traceable to PhEur T2545000
  traceable to USP 1696958
SMILES string   OCCN(CCO)CCO
InChI   1S/C6H15NO3/c8-4-1-7(2-5-9)3-6-10/h8-10H,1-6H2
InChI key   GSEJCLTVZPLZKY-UHFFFAOYSA-N

Description

General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standard. Trolamine belongs to the family of ethanolamines, offering a broad spectrum of applications due to its ability to combine the properties of both amines and alcohols. Its property as an organic base to form soluble neutralization products with insoluble acids is reported.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC2885 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
Flash Point(F) 
354.2 °F - closed cup
Flash Point(C) 
179 °C - closed cup
Protocols & Articles
Peer-Reviewed Papers
15

References

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