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PHR1587 Supelco

Thimerosal

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: 2-(Ethylmercuriomercapto)benzoic acid sodium salt, Ethylmercurithiosalicylic acid sodium salt, Mercury-([o-carboxyphenyl]thio)ethyl sodium salt, Sodium ethylmercurithiosalicylate, Thimerosal

  • CAS Number 54-64-8

  • Linear Formula 2-(C2H5HgS)C6H4CO2Na

  • Molecular Weight 404.81

  •  Beilstein/REAXYS Number 8169555

  •  EC Number 200-210-4

  •  MDL number MFCD00013062

  •  PubChem Substance ID 329823493

  •  NACRES NA.24

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, Pharmaceutical Secondary Standards, Pharmacopeia & Metrological Institutes Standards, T-Z More...
Quality Level   300
grade   certified reference material
  pharmaceutical secondary standard
packaging   pkg of 1 g
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
mp   234-237 °C (dec.) (lit.)
Featured Industry   Pharmaceutical (small molecule)
format   neat
pharmacopeia traceability   traceable to PhEur Y0000109
  traceable to USP 1659000
SMILES string   [Na+].CC[Hg]Sc1ccccc1C([O-])=O
InChI   1S/C7H6O2S.C2H5.Hg.Na/c8-7(9)5-3-1-2-4-6(5)10;1-2;;/h1-4,10H,(H,8,9);1H2,2H3;;/q;;2*+1/p-2
InChI key   RTKIYNMVFMVABJ-UHFFFAOYSA-L

Description

General description

Thimerosal belongs to the group of alkyl mercury compounds, widely used as a preservative in vaccine formulations.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Thimerosal may be used as a pharmaceutical reference standard for the quantification of the analyte in ophthalmic solutions using spectrophotometric technique.

Biochem/physiol Actions

Thimerosal is a sulfhydryl (thiol) oxidizing reagent capable of inhibiting a wide range of sulfhydryl-dependent enzymes and proteins such as PI3-kinase-dependent methionine synthase, glutamate transport receptors, and Na++K+ dependent ATPases.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA6959 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN 2025 6.1 / PGIII
WGK Germany 
WGK 3
Flash Point(F) 
482.0 °F - closed cup
Flash Point(C) 
250 °C - closed cup

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles
Peer-Reviewed Papers
15

References

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