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PHR1613 Supelco

Levothyroxine

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: 3,3′,5,5″-Tetraiodo-L-thyronine, 3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-L-alanine, L-Thyroxine, T4

  • CAS Number 51-48-9

  • Linear Formula HOC6H2(I)2OC6H2(I)2CH2CH(NH2)CO2H

  • Molecular Weight 776.87

  •  Beilstein/REAXYS Number 2228515

  •  EC Number 200-101-1

  •  MDL number MFCD00002595

  •  PubChem Substance ID 329823509

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Properties

Related Categories Additional Standards, Analytical Standards, Analytical/Chromatography, Chromatography, I-Z,
grade   certified reference material
  pharmaceutical secondary standard
InChI Key   XUIIKFGFIJCVMT-LBPRGKRZSA-N
packaging   pkg of 1 g
mp   223 °C (dec.) (lit.)
Featured Industry   Pharmaceutical (small molecule)
format   neat
pharmacopeia traceability   traceable to PhEur L0570000
  traceable to USP 1365000

Description

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

L-Thyroxine (T4) and triiodo-L-thyronine (T3) are iodine-containing hormones produced from thyroglobulin in the thyroid follicular cells. The stimulation of metabolic rate and regulation of growth and development by these hormones appear to be due to their effects on DNA transcription and, thus, protein synthesis.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC1514 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
YP2833500

Documents

Certificate of Analysis

Please Enter a Lot Number
Protocols & Articles

Articles

HPLC Analysis of Thyroxine Enantiomers on Astec® CHIROBIOTIC® TAG

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Thyroxine Enantiomers on Astec® CHIROBIOTIC® TAG
Keywords: Chromatography, Clinical, Forensic, High performance liquid chromatography, Hormones, Mass spectrometry

LC/MS Analysis of Thyroid Hormones on Ascentis® Express F5

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Thyroid Hormones on Ascentis® Express F5
Keywords: Chromatography, High performance liquid chromatography, Hormones, Liquid chromatography mass spectrometry, Mass spectrometry, Metabolism, Metabolites

LC/MS Analysis of thyroid hormones on Titan™ PFP

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of thyroid hormones on Titan™ PFP
Keywords: High performance liquid chromatography, Hormones, Liquid chromatography mass spectrometry, Mass spectrometry, Metabolism, Metabolites

LC/MS with Online Solid Phase Extraction (SPE-LC/MS) of Thyroid Hormones in Plasma on Ascentis® Express Phenyl-Hexyl using RP-Amide Traps

From our library of Articles, Sigma-Aldrich presents LC/MS with Online Solid Phase Extraction (SPE-LC/MS) of Thyroid Hormones in Plasma on Ascentis® Express Phenyl-Hexyl using RP-Amide Traps
Keywords: Chromatography, High performance liquid chromatography, Hormones, Liquid chromatography mass spectrometry, Mass spectrometry, Sample preparations, Separation, Solid phase extractions, Solvents

Related Products

related product

Product #

Description

Add to Cart

L0570000 Levothyroxine sodium, European Pharmacopoeia (EP) Reference Standard
1365000 Levothyroxine, United States Pharmacopeia (USP) Reference Standard

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