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PHR1665 Supelco

Chlorobenzene

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: Chlorobenzene

  • CAS Number 108-90-7

  • Empirical Formula (Hill Notation) C6H5Cl

  • Molecular Weight 112.56

  •  Beilstein/REAXYS Number 605632

  •  EC Number 203-628-5

  •  MDL number MFCD00000530

  •  PubChem Substance ID 329823541

  •  NACRES NA.24

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, C-D, Food & Beverage Standards, Food Contact Materials,
Quality Level   300
grade   certified reference material
  pharmaceutical secondary standard
vapor density   3.86 (vs air)
vapor pressure   11.8 mmHg ( 25 °C)
autoignition temp.   1178 °F
expl. lim.   7.1 %
packaging   ampule of 3x1.2 mL
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
refractive index   n20/D 1.524 (lit.)
bp   132 °C (lit.)
mp   −45 °C (lit.)
density   1.106 g/mL at 25 °C (lit.)
Featured Industry   Pharmaceutical (small molecule)
format   neat
pharmacopeia traceability   traceable to USP 1601361
SMILES string   Clc1ccccc1
InChI   1S/C6H5Cl/c7-6-4-2-1-3-5-6/h1-5H
InChI key   MVPPADPHJFYWMZ-UHFFFAOYSA-N

Description

General description

Chlorobenzenes find use in domestic as well as industrial applications such as solvents, degreasers, pesticides and chemical intermediates for the synthesis of various chemical compounds. They are regarded as environmental pollutants because of their hazardous nature.
Pharmaceutical secondary standard for application in quality control. Provides pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Chlorobenzene may be used as a reference organic solvent standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC1691 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
UN1134 - class 3 - PG 3 - Chlorobenzene
WGK Germany 
WGK 2
Flash Point(F) 
80.6 °F - closed cup
Flash Point(C) 
27.0 °C - closed cup
Protocols & Articles
Peer-Reviewed Papers
15

References

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