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PHR1690 Supelco

Disulfiram

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: Bis(diethylthiocarbamoyl) disulfide, Bis(diethylthiocarbamyl) disulfide, Disulfiram, TETD, Tetraethylthiuram disulfide

  • CAS Number 97-77-8

  • Linear Formula (C2H5)2NCSS2CSN(C2H5)2

  • Molecular Weight 296.54

  •  Beilstein/REAXYS Number 1712560

  •  EC Number 202-607-8

  •  MDL number MFCD00009048

  •  PubChem Substance ID 329823558

  •  NACRES NA.24

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, C-D, Food & Beverage Standards, Food Contact Materials,
Quality Level   300
grade   certified reference material
  pharmaceutical secondary standard
packaging   pkg of 1 g
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
mp   69-71 °C (lit.)
Featured Industry   Pharmaceutical (small molecule)
format   neat
pharmacopeia traceability   traceable to BP 132
  traceable to PhEur D2950000
  traceable to USP 1224008
SMILES string   CCN(CC)C(=S)SSC(=S)N(CC)CC
InChI   1S/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H3
InChI key   AUZONCFQVSMFAP-UHFFFAOYSA-N
Gene Information   human ... ALDH2(217)

Description

General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Disulfiram is clinically used in the treatment of chronic alcoholism.

Application

Disulfiram may be used as a pharmaceutical reference standard for the determination of the analyte in biological fluids and pharmaceutical formulations by high performance liquid chromatography and spectrophotometry, respectively.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Alcohol dehydrogenase inhibitor.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC2079 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Hazard statements 
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
WGK 3

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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