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Proguanil hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: Chlorguanide, N1-(4-Chlorophenyl)-N5-isopropylbiguanide, Proguanil hydrochloride

  • CAS Number 637-32-1

  • Empirical Formula (Hill Notation) C11H16ClN5·HCl

  • Molecular Weight 290.19

  •  EC Number 211-283-7

  •  MDL number MFCD01732193

  •  PubChem Substance ID 329823569

  •  NACRES NA.24

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, P-S, Pharmaceutical Secondary Standards, Pharmacopeia & Metrological Institutes Standards More...
Quality Level   300
grade   certified reference material
  pharmaceutical secondary standard
InChI Key   SARMGXPVOFNNNG-UHFFFAOYSA-N
packaging   pkg of 1 g
Featured Industry   Pharmaceutical (small molecule)
format   neat
pharmacopeia traceability   traceable to BP 297
  traceable to USP 1568040

Description

General description

Proguanil hydrochloride is a biguanide compound, widely used as an antimalarial drug. It exhibits sporontocidal activity, thereby rendering the gametocytes non-infective to the mosquito vector.
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Proguanil hydrochloride may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using high-performance liquid chromatography.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Chlorguanide (proguanil) is combined with atovaquone for malaria prophylaxis. The two compounds act synergistically to inhibit the plasmodial dihydrofolate reductase (DHFR) and interrupt the electron transport chain. Mutations in DHFR account for the development of resistant strains.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA7301 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

RIDADR 
UN 2811 6.1 / PGIII

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles
Peer-Reviewed Papers
15

References

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