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  • PHR1752 - Bupropion Hydrochloride Related Compound A

PHR1752 Supelco

Bupropion Hydrochloride Related Compound A

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: 2-(tert-Butylamino)-4′-chloropropiophenone hydrochloride, 2-(tert-butylamino)-3’-bromopiophenone hydrochloride

  • CAS Number 1049718-72-0

  • Empirical Formula (Hill Notation) C13H18ClNO · HCl

  • Molecular Weight 276.20

  •  NACRES NA.24



Related Categories A-B, Analytical Standards, Analytical/Chromatography, Bupropion Impurities, Pharmaceutical Impurities,
Quality Level   300
grade   certified reference material
  pharmaceutical secondary standard
packaging   pkg of 30 mg
Featured Industry   Pharmaceutical (small molecule)
format   neat
pharmacopeia traceability   traceable to USP 1078744


General description

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Bupropion hydrochloride (BUP) and its derivatives belong to a chemical class of aminoketones and are known for their antidepressant abilities. BUP selectively inhibits the neuronal reabsorption of catecholamines (noradrenalin and dopamine), has minimal effect on the recapture of indolamines (serotonin) and no inhibitory effect on monoamine oxidase. It is used as the non-nicotine pharmacological therapy for combating smoking in controlled release form.
Bupropion hydrochloride (BUP) may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by spectrophotometric and chromatographic techniques.


These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.


To see an example of a Certificate of Analysis for this material enter LRAA7916 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

GHS07  GHS07
Signal word 
Hazard statements 
Precautionary statements 
NONH for all modes of transport
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable


Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles


UHPLC Analysis of Bupropion and Five Related Compounds on Ascentis® Express C18

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Bupropion and Five Related Compounds on Ascentis® Express C18
Keywords: Anti-depressants, Clinical, Forensic, High performance liquid chromatography, Mass spectrometry, Pharmaceutical, Separation

Peer-Reviewed Papers


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