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PHR1759 Supelco

Thiamine Impurity E

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: 3-[(4-Amino-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methylthiazol-2(3H)-thione, Thioxothiamine

  • CAS Number 299-35-4

  • Empirical Formula (Hill Notation) C12H16N4OS2

  • Molecular Weight 296.41



Related Categories Analytical Standards, Analytical/Chromatography, Pharmaceutical Impurities, Pharmaceutical Secondary Standards, Pharmacopeia & Metrological Institutes Standards,
Quality Level   300
grade   certified reference material
  pharmaceutical secondary standard
packaging   pkg of 20 mg
Featured Industry   Pharmaceutical (small molecule)
format   neat


General description

Thiamine Impurity E is an impurity of B class vitamins such as thiamine. Thiamine is important for primary metabolism for all living organisms and is also used in the treatment or prevention of beriberi.


These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Thiamine may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using flow injection turbidimetric method and UV-Vis spectrophotometry.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.


To see an example of a Certificate of Analysis for this material enter LRAB3704 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

NONH for all modes of transport


Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers


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