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PHR1803 Supelco

Paclitaxel

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: Paclitaxel

  • CAS Number 33069-62-4

  • Empirical Formula (Hill Notation) C47H51NO14

  • Molecular Weight 853.91

  •  Beilstein/REAXYS Number 1420457

  •  MDL number MFCD00869953

  •  PubChem Substance ID 329823623

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Properties

Related Categories Additional Standards, Analytical Standards, Analytical/Chromatography, Chromatography, I-Z,
grade   certified reference material
  pharmaceutical secondary standard
InChI Key   RCINICONZNJXQF-MZXODVADSA-N
packaging   pkg of 200 mg
mp   213 °C (dec.) (lit.)
Featured Industry   Pharmaceutical (small molecule)
pharmacopeia traceability   traceable to PhEur Y0000698
  traceable to USP 1491332

Description

General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Biochem/physiol Actions

Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase. The microtubule damage induces apoptosis through a JNK-dependent pathway followed by a JNK-independent pathway, perhaps related to the activation of protein kinase A (PKA) or of Raf-1 kinase, resulting in phosphorylation of Bcl-2. A major metabolite via CYP2CB is 6α-hydroxypaclitaxel (6α-OHP).

Caution

Paclitaxel undergoes transesterification in methanol and hydrolyzes in aqueous solutions.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA9808 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles
Peer-Reviewed Papers
15

References

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