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PHR1807 Supelco

Sildenafil Citrate

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: 1-[[3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine citrate salt, 5-[2-Ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-1-methyl-3-propyl-4H-pyrazolo[5,4-e]pyrimidin-7-one citrate salt, Revatio, Sildenafil citrate salt, UK-92,480

  • CAS Number 171599-83-0

  • Empirical Formula (Hill Notation) C22H30N6O4S ·C6H8O7

  • Molecular Weight 666.70

  •  MDL number MFCD09026931

  •  PubChem Substance ID 329823626

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Properties

Related Categories Additional Standards, Analytical Standards, Analytical/Chromatography, Chromatography, I-Z,
grade   certified reference material
  pharmaceutical secondary standard
InChI Key   DEIYFTQMQPDXOT-UHFFFAOYSA-N
packaging   pkg of 500 mg
Featured Industry   Pharmaceutical (small molecule)
pharmacopeia traceability   traceable to PhEur Y0001578
  traceable to USP 1612561

Description

General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Biochem/physiol Actions

Sildenafil is a potent, selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5). Sildenafil is used to treat erectile dysfunction and pulmonary arterial hypertension. NO activates guanylate cyclase, which results in increased levels of cGMP, producing smooth muscle relaxation. Sildenafil enhances the effect of NO by inhibiting PDE5, which is responsible for degradation of cGMP.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB9121 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles

Articles

HPLC Analysis of Sildenafil and Impurities on Chromolith® High Resolution RP-18e

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Sildenafil and Impurities on Chromolith® High Resolution RP-18e
Keywords: High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Sildenafil and Impurities on Chromolith® Performance (3 mm I.D. columns)

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Sildenafil and Impurities on Chromolith® Performance (3 mm I.D. columns)
Keywords: High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Sildenafil and Impurities on Chromolith® Performance (4.6 mm I.D. columns)

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Sildenafil and Impurities on Chromolith® Performance (4.6 mm I.D. columns)
Keywords: High performance liquid chromatography, Pharmaceutical

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