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PHR1834 Supelco

Itraconazole

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: Itraconazole, Oriconazole, R51211, Sporanox

  • CAS Number 84625-61-6

  • Empirical Formula (Hill Notation) C35H38Cl2N8O4

  • Molecular Weight 705.63

  •  MDL number MFCD00870168

  •  PubChem Substance ID 329823629

  •  NACRES NA.24

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, E-J, Pharmaceutical Secondary Standards, Pharmacopeia & Metrological Institutes Standards More...
Quality Level   300
grade   certified reference material
  pharmaceutical secondary standard
InChI Key   VHVPQPYKVGDNFY-UHFFFAOYSA-N
packaging   pkg of 200 mg
Featured Industry   Pharmaceutical (small molecule)
pharmacopeia traceability   traceable to PhEur I7000000
  traceable to USP 1354251

Description

General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Biochem/physiol Actions

Itraconazole inhibits cytochrome P-450-dependent enzymes which results in the inhibition of ergosterol synthesis. It does so by interacting with 14-α demethylase, which is a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. Ergosterol is a crucial compenent of fungal cell membranes. Therefore, it′s inhibition results in increased cellular permeability causing leakage of cellular contents. Itraconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and phospholipid biosynthesis.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC0395 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

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From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Antifungals on Ascentis® Express Biphenyl
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LC/MS Analysis of Antifungals on Ascentis® Express Phenyl-Hexyl

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Antifungals on Ascentis® Express Phenyl-Hexyl
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UHPLC Analysis of Antifungals on Ascentis® Express C18

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Antifungals on Ascentis® Express C18
Keywords: Antifungals, Chromatography, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Pharmaceutical, Solvents

UHPLC Analysis of Antifungals on Titan™ C18

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Antifungals on Titan™ C18
Keywords: Antifungals, Chromatography, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Pharmaceutical, Solvents

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