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Azacitidine

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: 4-Amino-1-(β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one, 5-Azacytidine, Ladakamycin

  • CAS Number 320-67-2

  • Empirical Formula (Hill Notation) C8H12N4O5

  • Molecular Weight 244.20

  •  Beilstein/REAXYS Number 620461

  •  EC Number 206-280-2

  •  MDL number MFCD00006539

  •  NACRES NA.24

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Properties

Related Categories A-B, Analytical Standards, Analytical/Chromatography, Pharmaceutical Secondary Standards, Pharmacopeia & Metrological Institutes Standards More...
Quality Level   300
grade   certified reference material
  pharmaceutical secondary standard
packaging   pkg of 300 mg
mp   226-232 °C (dec.) (lit.)
Featured Industry   Pharmaceutical
pharmacopeia traceability   traceable to USP 1045520
SMILES string   NC1=NC(=O)N(C=N1)[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O
InChI   1S/C8H12N4O5/c9-7-10-2-12(8(16)11-7)6-5(15)4(14)3(1-13)17-6/h2-6,13-15H,1H2,(H2,9,11,16)/t3-,4-,5-,6-/m1/s1
InChI key   NMUSYJAQQFHJEW-KVTDHHQDSA-N
Gene Information   human ... DNMT1(1786), DNMT3A(1788)

Description

General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Biochem/physiol Actions

A potent growth inhibitor and cytotoxic agent; inhibits DNA methyltransferase, an important regulatory mechanism of gene expression, gene activation and silencing.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB1224 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
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