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PHR1932 Supelco

Isoniazid

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: 4-Pyridinecarboxylic acid hydrazide, INH, Isoniazid, Isonicotinic acid hydrazide, Isonicotinic hydrazide

  • CAS Number 54-85-3

  • Empirical Formula (Hill Notation) C6H7N3O

  • Molecular Weight 137.14

  •  Beilstein/REAXYS Number 119374

  •  EC Number 200-214-6

  •  MDL number MFCD00006426

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, E-J, Pharmaceutical Secondary Standards, Pharmacopeia & Metrological Institutes Standards More...
Quality Level   300
grade   certified reference material
  pharmaceutical secondary standard
InChI Key   QRXWMOHMRWLFEY-UHFFFAOYSA-N
packaging   pkg of 500 mg
mp   171-173 °C (lit.)
pharmacopeia traceability   traceable to BP 1083
  traceable to PhEur I0500000
  traceable to USP 1349706

Description

General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Biochem/physiol Actions

Antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Selectively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC3171 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis (COA)

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Protocols & Articles
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