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PHR2561 Supelco

Alpha Lipoic Acid

Synonym: (±)-α-Lipoic acid, (±)-1,2-Dithiolane-3-pentanoic acid, 6,8-Dithiooctanoic acid, DL-α-Lipoic acid, DL-6,8-Thioctic acid, Lip(S2)

  • CAS Number 1077-28-7

  • Empirical Formula (Hill Notation) C8H14O2S2

  • Molecular Weight 206.33

  •  Beilstein/REAXYS Number 81853

  •  MDL number MFCD00005474

Purchase

Properties

grade   certified reference material
  pharmaceutical secondary standard
description   Pharmaceutical Secondary Standard; Certified Reference Material
packaging   pkg of 1 g
pharmacopeia traceability   traceable to PhEur Y0000546
  traceable to USP 1368201
storage temp.   2-8°C
SMILES string   OC(=O)CCCCC1CCSS1
InChI   1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)
InChI key   AGBQKNBQESQNJD-UHFFFAOYSA-N

Description

General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Biochem/physiol Actions

Antioxidant and coenzyme needed for the activity of enzyme complexes such as those of pyruvate dehydrogenase and glycine decarboxylase. Exogenous thioctic acid is reduced intracellularly by two or more enzymes. The reduced form then influences a number of cell processes by direct radical scavenging, recycling of other antioxidants, increasing glutathione synthesis, and modulating transcription factor activity particularly that of NF-κB. Decreases the phagocytosis of myelin by macrophages.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC6145 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Hazard statements 
WGK Germany 
WGK 2
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles
Related Products

related product

Product #

Description

Add to Cart

Y0000546 Thioctic acid, European Pharmacopoeia (EP) Reference Standard
Y0000592 Thioctic acid for system suitability, European Pharmacopoeia (EP) Reference Standard
1368201 Alpha Lipoic Acid, United States Pharmacopeia (USP) Reference Standard

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