S2002 Sigma-Aldrich

Sodium azide

ReagentPlus®, ≥99.5%

Synonym: Hydrazoic acid sodium salt, NSC 3072



Related Categories Azide Sources - Diazo Transfer, Biochemicals and Reagents, C-X Bond Formation (Non-Halogen), Chemical Synthesis, Enzyme Inhibitors,
Quality Level   200
biological source   synthetic (inorganic)
product line   ReagentPlus®
assay   ≥99.5%
form   powder
mp   370-425 °C
solubility   soluble 65 g/L at 20 °C (completely)
SMILES string   [Na]N=[N+]=[N-]
InChI   1S/N3.Na/c1-3-2;/q-1;+1


General description

Sodium azide is commonly used as a bacteriostatic preservative for biological samples and also as a source to generate gas in automobile airbags. It is also a metabolic inhibitor, which inhibits oxidative phosphorylation.


Baylis-Hillman acetates such as ethyl 2-(acetoxyphenylmethyl)acrylate can undergo nucleophilic displacement by sodium azide in aqueous medium to form ethyl (E)-2-azidomethyl-3-phenylpropenoate.

Catalyst for:
• Oxidative decarboxylation
• Michael addition reactions

Reagent for synthesis of
• Blue fluorescent copolymers
• Metal phosphonates
• Arenes via aminations

Involved in regioselective synthesis of prianosin B


2 kg in poly bottle

25 kg in poly drum

5, 25, 100, 500 g in poly bottle

Legal Information

ReagentPlus is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Signal word 
Hazard statements 
Target organs 
Supplemental Hazard Statements 
UN 1687 6.1 / PGII
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable


Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Frequently Asked Questions

What concentrations ofProduct S2002, Sodium azide, are used as a preservative?
Typical concentrations for use are from 0.02 % to 0.1 %.
How can I determine the concentration of sodium azide in solution?
Sodium azide forms a 3,5-dinitrobenzoyl derivative that can be quantified by liquid chromatography. This method is reported in the Journal of Chromatography, 5, 597 (1982).
Are there any hazards associated with the disposal of Product S2002, Sodium azide?
Sodium azide can form metal azides. If you have metal pipes for your plumbing, you should not dispose of solutions down them.
How stable are solutions of Product S2002, Sodium azide?
At a neutral pH sodium azide solutions are fairly stable. Under acidic conditions it is converted to hydrazoic acid, a volatile gas.
How does Product S2002, Sodium azide, inhibit certain metalloenzymes?
The mechanism of sodium azide inhibition may be due to metal ion complexation and displacement from the enzyme.
Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How do I find price and availability?
There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 or view local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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