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S3674 Sigma-Aldrich

Succinic acid

Green Alternative

BioXtra, ≥99.0%

Synonym: Butanedioic acid

  • CAS Number 110-15-6

  • Linear Formula HOOCCH2CH2COOH

  • Molecular Weight 118.09

  •  Beilstein/REAXYS Number 1754069

  •  EC Number 203-740-4

  •  MDL number MFCD00002789

  •  PubChem Substance ID 24899568

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Properties

Related Categories 12 Principles Aligned Products, Bio-based Greener Alternatives, Building Blocks, C1 to C5, Carbonyl Compounds,
InChI Key   KDYFGRWQOYBRFD-UHFFFAOYSA-N
product line   BioXtra
assay   ≥99.0%
greener alternative product characteristics   Use of Renewable Feedstocks
Learn more about the Principles of Green Chemistry.
impurities   ≤0.0005% Phosphorus (P)
  ≤0.01% Insoluble matter
ign. residue   ≤0.02%
bp   235 °C (lit.)
mp   184-186 °C (lit.)
solubility   H2O: 0.5 M, clear, colorless
anion traces   chloride (Cl-): ≤0.001%
  sulfate (SO42-): ≤0.003%
cation traces   Al: ≤0.0005%
  Ca: ≤0.001%
  Cu: ≤0.0005%
  Fe: ≤0.0005%
  K: ≤0.005%
  Mg: ≤0.0005%
  NH4+: ≤0.05%
  Na: ≤0.005%
  Pb: ≤0.001%
  Zn: ≤0.0005%

Description

Application

Succinic acid has been used:
• in succinate dehydrogenase mitochondrial assay.
• as an internal standard in mass spectroscopy.
• as succinate dehydrogenase substrate in oxygraph analysis to measure respiration rates.

Packaging

1 kg in poly bottle

100, 250 g in poly bottle

Biochem/physiol Actions

Succinic acid is a byproduct of anaerobic fermentation in microbes. It is a dicarboxylic acid and an intermediate in Kreb′s cycle. Polymorphism in succinate dehydrogenase leads to succinate accumulation. High levels of succinate impairs 2-oxoglutarate epigenetic signalling. Succinate levels may modulate tumor progression. Succinate inhibits histone demethylation and may contribute to epigenetic changes. Succinate is crucial for interleukin-1 β (IL-1β) synthesis during inflammation and immune signalling.

Safety & Documentation

Safety Information

Symbol 
GHS05  GHS05
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
1
RTECS 
WM4900000

Documents

Certificate of Analysis

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Certificate of Origin

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Protocols & Articles

Articles

MSMLS Online Plate Map

Metabolite descriptors included with the software download upon purchase of the product include: Name, Parent CID, molecular formula, molecular weight, CAS, ChEBI, HMDB ID, PubChem Compound and Subst...
Keywords: Mass spectrometry, Metabolites

Peer-Reviewed Papers
15

References

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