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T0600000 Sigma-Aldrich

Tetracycline hydrochloride

European Pharmacopoeia (EP) Reference Standard

  • CAS Number 64-75-5

  • Empirical Formula (Hill Notation) C22H24N2O8 · HCl

  • Molecular Weight 480.90

  •  Beilstein/REAXYS Number 3844873

  •  MDL number MFCD00078142

  •  PubChem Substance ID 329826277

  •  NACRES NA.24

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, EP Standards, EP Standards S - T, Pharmacopeia & Metrological Institutes Standards More...
InChI Key   XMEVHPAGJVLHIG-FMZCEJRJSA-N
form   neat
mp   220-223 °C (lit.)
Featured Industry   Pharmaceutical (small molecule)
format   neat

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Biochem/physiol Actions

Mode of Action: Tetracycline passively diffuses through proin channels in the cell membrane, binding to 30S ribosomes and inhibits protein synthesis by preventing access of aminoacyl tRNA to the acceptor site on the mRNA-ribosome complex. It also binds to the bacterial 50S ribosomal subunit, altering the membrane and causing intracellular components to leak from bacterial cells. The inhibitory effects can be reversed by washing, suggesting that it is the reversibly bound antibiotic, and not the irreversibly bound drug, that is responsible for antibacterial action.

Mode of Resistance: The effects are inactivated via a loss of cell wall permeability.

Antimicrobial spectrum: Includes a wide range of antimicrobial activity against gram-positive and gram-negative bacteria.

Packaging

Unit quantity: 80 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Caution

Please find SDS provided by EDQM here..

Other Notes

Sales restrictions may apply.

Safety & Documentation

Safety Information

RIDADR 
UN 3077 9 / PGIII

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

LC/MS/MS Analysis of Tetracycline Antibiotics on Kromasil® Eternity™ C18

From our library of Articles, Sigma-Aldrich presents LC/MS/MS Analysis of Tetracycline Antibiotics on Kromasil® Eternity™ C18
Keywords: Antibiotics, Chromatography, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Metabolites

Peer-Reviewed Papers
15

References

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