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T176 Supelco

4-Hydroxytamoxifen

analytical standard, (E) and (Z) isomers (50:50)

Synonym: 4-(1-[4-(Dimethylaminoethoxy)phenyl]-2-phenyl-1-butenyl)phenol, 4-OHT, cis/trans-4-Hydroxytamoxifen

  • CAS Number 68392-35-8

  • Empirical Formula (Hill Notation) C26H29NO2

  • Molecular Weight 387.51

  •  PubChem Substance ID 24899989

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Properties

Related Categories Additional Drugs, Analytical Standards, Analytical/Chromatography, Antibiotics, Antibiotics A to Z,
grade   analytical standard
InChI Key   ZJLDABGSDWXVGE-BDSXMVAQSA-N
form   neat
  powder
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
solubility   ethanol: 20 mg/mL
Featured Industry   Pharmaceutical (small molecule)
Mode of action   enzyme | inhibits
antibiotic activity spectrum   neoplastics
format   neat
Gene Information   human ... ESR1(2099), ESR2(2100), ESRRG(2104), IL6(3569)
rat ... Ar(24208), Esr1(24890), Esr2(25149)

Description

Biochem/physiol Actions

Metabolite of the chemotherapeutic drug tamoxifen, exhibiting more potent estrogen agonist/antagonist activity than the parent drug. Also active as intra-membranous inhibitor of lipid peroxidation.

Packaging

10, 50 mg in poly bottle

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Hazard statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
SL1210000

Documents

Certificate of Analysis

Certificate of Origin


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Protocols & Articles

Articles

HPLC Analysis of Tamoxifen E/Z isomers and Related Compounds on Ascentis® Express RP-Amide

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Tamoxifen E/Z isomers and Related Compounds on Ascentis® Express RP-Amide
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

Peer-Reviewed Papers
15

References

Related Products

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