EMAIL THIS PAGE TO A FRIEND
T176 Supelco

4-Hydroxytamoxifen

analytical standard, (E) and (Z) isomers (50:50)

Synonym: 4-(1-[4-(Dimethylaminoethoxy)phenyl]-2-phenyl-1-butenyl)phenol, 4-OHT, cis/trans-4-Hydroxytamoxifen

  • CAS Number 68392-35-8

  • Empirical Formula (Hill Notation) C26H29NO2

  • Molecular Weight 387.51

  •  PubChem Substance ID 24899989

  •  NACRES NA.24

Purchase

Properties

Related Categories Additional Drugs, Analytical Standards, Analytical/Chromatography, Antibiotics, Antibiotics A to Z,
Quality Level   200
grade   analytical standard
form   neat
  powder
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
solubility   ethanol: 20 mg/mL
Featured Industry   Forensics and Toxicology
Pharmaceutical (small molecule)
Mode of action   enzyme | inhibits
antibiotic activity spectrum   neoplastics
format   neat
SMILES string   CC\C(c1ccccc1)=C(/c2ccc(O)cc2)c3ccc(OCCN(C)C)cc3.CC\C(c4ccccc4)=C(\c5ccc(O)cc5)c6ccc(OCCN(C)C)cc6
InChI   1S/2C26H29NO2/c2*1-4-25(20-8-6-5-7-9-20)26(21-10-14-23(28)15-11-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h2*5-17,28H,4,18-19H2,1-3H3/b26-25+;26-25-
InChI key   ZJLDABGSDWXVGE-BDSXMVAQSA-N
Gene Information   human ... ESR1(2099), ESR2(2100), ESRRG(2104), IL6(3569)
rat ... Ar(24208), Esr1(24890), Esr2(25149)

Description

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Packaging

10, 50 mg in poly bottle

Biochem/physiol Actions

Metabolite of the chemotherapeutic drug tamoxifen, exhibiting more potent estrogen agonist/antagonist activity than the parent drug. Also active as intra-membranous inhibitor of lipid peroxidation.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Hazard statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
SL1210000

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number

Certificate of Origin (COO)

Please Enter a Lot Number
Protocols & Articles

Articles

HPLC Analysis of Tamoxifen E/Z isomers and Related Compounds on Ascentis® Express RP-Amide

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Tamoxifen E/Z isomers and Related Compounds on Ascentis® Express RP-Amide
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?