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T9159 Sigma-Aldrich

Trichloroacetic acid

BioXtra, ≥99.0%

Synonym: TCA

  • CAS Number 76-03-9

  • Linear Formula Cl3CCOOH

  • Molecular Weight 163.39

  •  Beilstein/REAXYS Number 970119

  •  EC Number 200-927-2

  •  MDL number MFCD00004177

  •  PubChem Substance ID 24900586

  •  NACRES NB.22

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Properties

Related Categories Acids & Bases, Acids and Bases, Biochemicals and Reagents, Core Bioreagents, Denaturation,
Quality Level   200
vapor density   <1 (vs air)
vapor pressure   1 mmHg ( 51 °C)
product line   BioXtra
assay   ≥99.0%
impurities   ≤0.0005% Phosphorus (P)
  ≤0.1% Insoluble matter
ign. residue   ≤0.03%
refractive index   n20/D 1.62 (lit.)
bp   196 °C (lit.)
mp   54-58 °C (lit.)
solubility   H2O: 0.5 M at 20 °C, clear, colorless
density   1.62 g/mL at 25 °C (lit.)
anion traces   sulfate (SO42-): ≤0.05%
cation traces   Al: ≤0.0005%
  Ca: ≤0.005%
  Cu: ≤0.0005%
  Fe: ≤0.001%
  K: ≤0.01%
  Mg: ≤0.0005%
  NH4+: ≤0.05%
  Na: ≤0.005%
  Pb: ≤0.001%
  Zn: ≤0.0005%
storage temp.   2-8°C
SMILES string   OC(=O)C(Cl)(Cl)Cl
InChI   1S/C2HCl3O2/c3-2(4,5)1(6)7/h(H,6,7)
InChI key   YNJBWRMUSHSURL-UHFFFAOYSA-N

Description

General description

Trichloroacetic acid (TCA) is an important metabolic product of trichloroethylene (TCE) metabolism.

Application

Trichloroacetic acid has been used:
• for protein precipitation
• as a component in the extract solution used for the measurement of malondialdehyde and glutathione
• to precipitate the transfected and treated cells in [3H]-thymidine incorporation assay

Traditionally used to precipitate protein. Has been used to determine protein concentration by quantitative precipitation. Used as decalcifier and fixative in microscopy.

Packaging

100, 250, 500 g in glass bottle

Biochem/physiol Actions

TCA might act as a carcinogen, targeting liver. It might be used as an acid decalcifying agent. TCA helps in nuclear staining.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN 1839 8 / PGII
WGK Germany 
2
RTECS 
AJ7875000
Flash Point(F) 
>235.4 °F
Flash Point(C) 
>113 °C

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Single- & multi-channel pipettes from BRAND
Protocols & Articles
Peer-Reviewed Papers
15

References

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