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Y0000592

Thioctic acid for system suitability

European Pharmacopoeia (EP) Reference Standard

Synonym: (±)-α-Lipoic acid, (±)-1,2-Dithiolane-3-pentanoic acid, 6,8-Dithiooctanoic acid, DL-α-Lipoic acid, DL-6,8-Thioctic acid, Lip(S2)

  • CAS Number 1077-28-7

  • Empirical Formula (Hill Notation) C8H14O2S2

  • Molecular Weight 206.33

  •  Beilstein/REAXYS Number 81853

  •  MDL number MFCD00005474

  •  PubChem Substance ID 329831039

  •  NACRES NA.24

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, EP Standards, EP Standards S - T, Pharmacopeia & Metrological Institutes Standards More...
grade   pharmaceutical primary standard
form   neat
mfr. no.   EDQM
Featured Industry   Pharmaceutical (small molecule)
format   neat
storage temp.   2-8°C
SMILES string   OC(=O)CCCCC1CCSS1
InChI   1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)
InChI key   AGBQKNBQESQNJD-UHFFFAOYSA-N

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Biochem/physiol Actions

Antioxidant and coenzyme needed for the activity of enzyme complexes such as those of pyruvate dehydrogenase and glycine decarboxylase. Exogenous thioctic acid is reduced intracellularly by two or more enzymes. The reduced form then influences a number of cell processes by direct radical scavenging, recycling of other antioxidants, increasing glutathione synthesis, and modulating transcription factor activity particularly that of NF-κB. Decreases the phagocytosis of myelin by macrophages.

Packaging

Unit quantity: 15 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Caution

Please find SDS provided by EDQM here..

Other Notes

Sales restrictions may apply.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Hazard statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 2
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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PHR2561 Alpha Lipoic Acid

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