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Y0001177

Dexamethasone for system suitability

European Pharmacopoeia (EP) Reference Standard

Synonym: (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione, 9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione, 9α-Fluoro-16α-methylprednisolone, Dexamethasone, Prednisolone F

  • CAS Number 50-02-2

  • Empirical Formula (Hill Notation) C22H29FO5

  • Molecular Weight 392.46

  •  Beilstein/REAXYS Number 2066651

  •  MDL number MFCD00064136

  •  PubChem Substance ID 329831293

  •  NACRES NA.24

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, EP Standards, EP Standards C - D, Pharmacopeia & Metrological Institutes Standards More...
biological source   synthetic
grade   pharmaceutical primary standard
Agency/Method   EP
form   neat
  powder
packaging   pkg of 10 mg
mfr. no.   EDQM
storage condition   protect from light
mp   262-264 °C (lit.)
  262-264 °C
solubility   water: <0.1 g/L
Featured Industry   Pharmaceutical (small molecule)
format   neat
shipped in   ambient
storage temp.   2-8°C
SMILES string   C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO
InChI   1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
InChI key   UREBDLICKHMUKA-CXSFZGCWSA-N
Gene Information   human ... NR3C1(2908)

Description

General description

Dexamethasone belongs to the class of synthetic glucocorticoid steroid drugs.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Dexamethasone is used as a pharmaceutical primary standard to quantify the analyte in pharmaceutical formulations using liquid chromatography (LC) technique.

Biochem/physiol Actions

Glucocorticoid anti-inflammatory agent. Regulates T cell survival, growth, and differentiation. Inhibits the induction of nitric oxide synthase.

Packaging

Unit quantity: 10 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Caution

Please find SDS provided by EDQM here..

Other Notes

Sales restrictions may apply.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Target organs 
Respiratory system
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 2
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Dexamethasone: An HPLC Assay and Impurity Profiling Following the USP

A simple, precise, and sensitive reversed-phase high performance liquid chromatography (RP-HPLC) gradient method was adapted for establishing traceability and total chromatographic analysis of dexame...
Keywords: Chromatography, High performance liquid chromatography, Reversed-phase chromatography, Separation

Peer-Reviewed Papers
15

References

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