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Y0001596 Sigma-Aldrich

Diacerein impurity B

European Pharmacopoeia (EP) Reference Standard

Synonym: 1,8-Dihydroxy-3-(hydroxymethyl)anthraquinone, 1,8-Dihydroxy 3-hydroxymethylanthraquinone, 3-Hydroxymethylchrysazine, Aloe-emodin, Rhabarberone

  • CAS Number 481-72-1

  • Empirical Formula (Hill Notation) C15H10O5

  • Molecular Weight 270.24

  •  Beilstein/REAXYS Number 2059062

  •  MDL number MFCD00017373

  •  PubChem Substance ID 329831502

  •  NACRES NA.24

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, EP Standards, EP Standards C - D, Pharmacopeia & Metrological Institutes Standards More...
biological source   synthetic
InChI Key   YDQWDHRMZQUTBA-UHFFFAOYSA-N
form   neat
Agency/Method   EP
Featured Industry   Pharmaceutical (small molecule)
format   neat
storage temp.   2-8°C

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Biochem/physiol Actions

Laxative/cathartic compound; increases the contraction of intestinal smooth muscle by releasing endogenous acetylcholine. Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, thus inducing a permeability transition that sets in motion a series of events culminating in cellular apoptosis. Genotoxicity and mutagenicity appear to be due to the inhibition of topoisomerase II activity by aloe emodin.

Packaging

Unit quantity: 20 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Caution

Please find SDS provided by EDQM here..

Other Notes

Sales restrictions may apply.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

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Protocols & Articles
Peer-Reviewed Papers
15

References

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