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123226 Sigma-Aldrich

Anisole

ReagentPlus®, 99%

Synonym: Methoxybenzene, Methyl phenyl ether

  • CAS Number 100-66-3

  • Linear Formula CH3OC6H5

  • Molecular Weight 108.14

  •  Beilstein/REAXYS Number 506892

  •  EC Number 202-876-1

  •  MDL number MFCD00008354

  •  eCl@ss 39023603

  •  PubChem Substance ID 329749709

  •  NACRES NA.21

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Properties

Related Categories ReagentPlus, ReagentPlus Solvent Grade Products, ACS and Reagent Grade Solvents, Amber Glass Bottles, Carbon Steel Cans with NPT Threads,
Quality Level   200
vapor density   3.7 (vs air)
vapor pressure   10 mmHg ( 42.2 °C)
product line   ReagentPlus®
assay   99%
form   liquid
autoignition temp.   887 °F
expl. lim.   0.34-6.3 %
refractive index   n20/D 1.516 (lit.)
bp   154 °C (lit.)
mp   −37 °C (lit.)
density   0.995 g/mL at 25 °C (lit.)
SMILES string   COc1ccccc1
InChI   1S/C7H8O/c1-8-7-5-3-2-4-6-7/h2-6H,1H3
InChI key   RDOXTESZEPMUJZ-UHFFFAOYSA-N

Description

General description

Anisole can be obtained from the reaction between methyl formate and sodium phenolate or potassium phenolate at high temperature and pressure.

Application

Anisole has been used as a dopant to improve the sensitivity of photoionization at atmospheric pressure, which can be used as a source in the detection of nonpolar compounds using liquid chromatography coupled with mass spectrometry. It has also been used to improve the molecular fragmentation which further increases the background signal intensity in hyperthermal surface ionization source, when coupled with time-of-flight mass spectrometer.

Packaging

1, 4 L in glass bottle

100 mL in glass bottle

18 L in steel drum

Legal Information

ReagentPlus is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
GHS02  GHS02
Signal word 
Warning
Hazard statements 
Precautionary statements 
Supplemental Hazard Statements 
EUH066
RIDADR 
UN 2222 3 / PGIII
WGK Germany 
WGK 2
Flash Point(F) 
125.1 °F - closed cup
Flash Point(C) 
51.7 °C - closed cup

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Pressure-Temperature Calculator for Solvents

*Calculations provide estimated results based on Antoine's Coefficients and their associated temperature range values. Antoine's Coefficients were obtained from the National Institute of Standards an...

Protocols

Fmoc SPPS Protocols for Cysteine Peptides

Peptides containing Cys can exist in either reduced (sulfhydryl) or oxidized inter/intra chain disulfide bonded forms. The synthesis of peptides containing Cys, therefore, presents special challenges...
Keywords: Alkylations, Asymmetric synthesis, Buffers, Centrifugation, Coupling reactions, Cyclizations, Eliminations, Evaporation, Filtration, High performance liquid chromatography, Hormones, Iodinations, Oxidations, Peptide synthesis, Purification, Racemizations, Rearrangements, Reductions, Solid phase peptide synthesis, Solvents, Thiolysis

Peer-Reviewed Papers
15

References

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