221465 Sigma-Aldrich

Sodium hydroxide

ACS reagent, ≥97.0%, pellets

Synonym: ‘Caustic soda’



Related Categories ACS Grade Acids & Bases, Acids & Bases, Acids and Bases, Adsorbents, Filter Aids and Drying Agents, Analytical Reagents,
Quality Level   200
grade   ACS reagent
vapor density   >1 (vs air)
vapor pressure   <18 mmHg ( 20 °C)
  3 mmHg ( 37 °C)
assay   ≥97.0%
form   pellets
application(s)   cell culture | mammalian: suitable
  titration: suitable
impurities   ≤0.001% N compounds
  ≤0.02% NH4OH ppt.
  ≤1.0% Na2CO3
mp   318 °C (lit.)
solubility   water: soluble 1,260 g/L at 20 °C
density   2.13 g/cm3 at 20 °C
anion traces   chloride (Cl-): ≤0.005%
  phosphate (PO43-): ≤0.001%
  sulfate (SO42-): ≤0.003%
cation traces   Fe: ≤0.001%
  Hg: ≤0.1 ppm
  K: ≤0.02%
  Ni: ≤0.001%
  heavy metals (as Ag): ≤0.002%
SMILES string   [OH-].[Na+]
InChI   1S/Na.H2O/h;1H2/q+1;/p-1


General description

Sodium hydroxide (NaOH) also known as caustic soda is a water soluble inorganic base with a wide range of industrial application such as titration, dissolution testing and in impinger to remove acidic gases. It participates in the oxidation of glycerol catalyzed by Au/charcoal or Au/graphite. It participates in solvent-free aldol condensation reaction.


Sodium hydroxide (NaOH) was used in the following processes:
• Preparation of sodium 3,3′-bis(sulfonato)-4,4′-bis(chloroacetamido)azobenzene (BSBCA) that is utilized in protein cross-linking techniques.
• Preparation of electrolyte solution to study the effect of electrolyte composition on the conversion of CO2 to CO by electrochemical reduction.
• Preparation of CSK (cytoskeleton) buffer for the three-dimensional (3D) slide method of preserving the 3D chromatin structure of testicular germ cells.
• Synthesis of ZSMs (zeolite socony mobils).
Sodium hydroxide may be employed for the deterimination of specific surface area of colloidal silica, via titration. It may be employed for the direct oxidation of sodium borohydride, which was investigated by cyclic and linear voltammetry, chronoamperometry and chronopotentiometry. It may be used to prepare citrate buffer and borate buffer. It may be used in the synthesis of :
• alkylaryl amidosulfobetaines
• (3 -[4-teroctylphenoxyethoxyethoxyethyl] dimethylammonio propane sulfonate (XOSB)
• trisulfobetaines (TriSBn)

Sodium hydroxide may be used as a base in titration methods, dissolution testing, for adjusting pH and in the impinger to remove acidic gases.
It may be used in the following processes:
• Conversion of glycerol to glyceric acid in the presence of gold catalyst.
• Palladium-catalyzed cross-coupling reaction between vinylalkoxysilanes and aryl bromides or chlorides to form styrenes.


1, 2.5 kg in poly bottle

12, 25, 50 kg in poly drum

25, 500, 6×500 g in poly bottle

Other Notes

Go to Redi-Dri Product Listing 795429

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Safety & Documentation

Safety Information

GHS05  GHS05
Signal word 
Hazard statements 
UN 1823 8 / PGII
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable


Certificate of Analysis (COA)

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Certificate of Origin (COO)

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