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299537 Sigma-Aldrich

Trifluoroacetic acid

≥99%, for protein sequencing

Synonym: TFA

  • CAS Number 76-05-1

  • Linear Formula CF3COOH

  • Molecular Weight 114.02

  •  Beilstein/REAXYS Number 742035

  •  EC Number 200-929-3

  •  MDL number MFCD00004169

  •  PubChem Substance ID 329753402

  •  NACRES NA.21

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Properties

Related Categories Amber Glass Bottles, Analytical Reagents, Analytical/Chromatography, Biotech, Biotech Solvents,
Quality Level   100
vapor density   3.9 (vs air)
vapor pressure   97.5 mmHg ( 20 °C)
type   for protein sequencing
assay   ≥99%
form   liquid
impurities   <0.05% water
evapn. residue   <0.005%
refractive index   n20/D 1.3 (lit.)
pH   1 (20 °C, 10  g/L)
bp   72.4 °C (lit.)
mp   −15.4 °C (lit.)
density   1.489 g/mL at 20 °C (lit.)
SMILES string   OC(C(F)(F)F)=O
InChI   1S/C2HF3O2/c3-2(4,5)1(6)7/h(H,6,7)
InChI key   DTQVDTLACAAQTR-UHFFFAOYSA-N

Description

Packaging

25, 100, 500 g in glass bottle

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN 2699 8 / PGI
WGK Germany 
WGK 2
RTECS 
AJ9625000
Flash Point(F) 
No data available
Flash Point(C) 
No data available

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

BIOshell™ IgG 1000 Å C4 UHPLC Column for Improved Biomacromolecule Separations

Monoclonal antibodies (mAbs) are widely manufactured by many biopharmaceutical companies to treat a myriad of diseases ranging from Alzheimer’s disease, Parkinson’s disease, ulcerative colitis, and m...
Keywords: Amplification, Chromatography, Diffusion, Diseases, High performance liquid chromatography, Mass spectrometry, Methylations, Microscopy, Oxidations, Pesticides, Pharmaceutical, Phosphorylations, Reversed-phase chromatography, Scanning electron microscopy, Solid phase peptide synthesis

Fast UHPLC Analysis for IdeS Fragments of SiLu™Lite SigmaMAb Universal Antibody Standard on BIOshell A400 Protein C4

Both top-down and bottom-up approaches to protein characterization have their advantages and limitations. One such limitation of the top-down approach, particularly with large proteins, is the need f...
Hillel Brandes, and Stacy Shollenberger
Reporter US Volume 34.1
Keywords: Chromatography, Mass spectrometry, Reductions, Reversed-phase chromatography, Separation

HPLC Analysis of Benalaxyl Enantiomers on Astec(R) Cellulose DMP in Normal Phase Mode

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Benalaxyl Enantiomers on Astec(R) Cellulose DMP in Normal Phase Mode
Keywords: Asymmetric synthesis, Fungicides, Metabolites, Pesticides, Separation

HPLC Analysis of Tebuconazole Enantiomers on Astec(R) Cellulose DMP in Normal Phase Mode

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Tebuconazole Enantiomers on Astec(R) Cellulose DMP in Normal Phase Mode
Keywords: Asymmetric synthesis, Fungicides, Metabolites, Pesticides, Separation

HPLC Analysis of Tetraconazole Enantiomers on Astec(R) Cellulose DMP in Normal Phase Mode

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Tetraconazole Enantiomers on Astec(R) Cellulose DMP in Normal Phase Mode
Keywords: Asymmetric synthesis, Fungicides, Metabolites, Pesticides, Separation

Pressure-Temperature Calculator for Solvents

*Calculations provide estimated results based on Antoine's Coefficients and their associated temperature range values. Antoine's Coefficients were obtained from the National Institute of Standards an...

Threading the Molecular Needle: The Importance of Particle Pore Diameter for Biomacromolecule Separations

Recently, the evolution of middle to large biomacromolecules such as peptides or proteins is apparent in the market of pharmaceutical drugs in addition to traditional active ingredients based on smal...
Keywords: Adsorption, Chromatography, Clinical, Diffusion, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Methylations, Oxidations, Pharmaceutical, Phosphorylations, Separation, Solid phase peptide synthesis

UHPLC Analyses of Reduced Infliximab on BIOshell™ IgG 1000 Ã… C4 and BIOshell A400 Protein C4

From our library of Articles, Sigma-Aldrich presents UHPLC Analyses of Reduced Infliximab on BIOshell™ IgG 1000 Ã… C4 and BIOshell A400 Protein C4
Keywords: High performance liquid chromatography, Pharmaceutical, Reductions

UHPLC Analysis of A Monoclonal Antibody System Suitability Standard on BIOshell™ IgG 1000 Ã… C4

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of A Monoclonal Antibody System Suitability Standard on BIOshell™ IgG 1000 Ã… C4
Keywords: Glycosylations

UHPLC Analysis of Glembatumumab Vedotin Antibody Drug Conjugate on BIOshell™ A400 Protein C4

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Glembatumumab Vedotin Antibody Drug Conjugate on BIOshell™ A400 Protein C4
Keywords: Cancer

UHPLC Analysis of Human IgA on BIOshell™ IgG 1000 Ã… C4

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Human IgA on BIOshell™ IgG 1000 Ã… C4
Keywords: Anti-inflammatory agents

UHPLC Analysis of Human IgM on BIOshell™ IgG 1000 Ã… C4

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Human IgM on BIOshell™ IgG 1000 Ã… C4

UHPLC Analysis of Intact Infliximab on BIOshell™ A400 Protein C4

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Intact Infliximab on BIOshell™ A400 Protein C4
Keywords: Diseases, Pharmaceutical

UHPLC Analysis of Intact Infliximab on BIOshell™ IgG 1000 Ã… C4

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Intact Infliximab on BIOshell™ IgG 1000 Ã… C4
Keywords: Diseases, Pharmaceutical

UHPLC Analysis of Orthoclone OKT3 IgG2 Monoclonal Antibody on BIOshell™ A400 Protein C4

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Orthoclone OKT3 IgG2 Monoclonal Antibody on BIOshell™ A400 Protein C4
Keywords: Chromatography, Clinical, Reversed-phase chromatography

UHPLC Analysis of Orthoclone OKT3 Monoclonal Antibody on BIOshell™ IgG 1000 Ã… C4

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Orthoclone OKT3 Monoclonal Antibody on BIOshell™ IgG 1000 Ã… C4
Keywords: Chromatography, Clinical, Reversed-phase chromatography, Solid phase peptide synthesis

UHPLC Analysis of Rabbit Secretory IgA on BIOshell™ IgG 1000 Ã… C4

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Rabbit Secretory IgA on BIOshell™ IgG 1000 Ã… C4

UHPLC Analysis of SigmaMAb Universal Antibody Standard on BIOshell™ IgG 1000 Ã… C4

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of SigmaMAb Universal Antibody Standard on BIOshell™ IgG 1000 Ã… C4

Peer-Reviewed Papers
15

References

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