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31437 Sigma-Aldrich

Sodium bicarbonate

puriss. p.a., ACS reagent, reag. Ph. Eur., ≥99.7%

Synonym: Sodium hydrogen carbonate

  • CAS Number 144-55-8

  • Linear Formula NaHCO3

  • Molecular Weight 84.01

  •  Beilstein/REAXYS Number 4153970

  •  EC Number 205-633-8

  •  MDL number MFCD00003528

  •  PubChem Substance ID 329753766

  •  NACRES NA.85

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Properties

Related Categories Analytical Reagents, Analytical Reagents for General Use, Analytical/Chromatography, Essential Chemicals, Puriss p.a. ACS,
grade   ACS reagent
Agency/Method   reag. Ph. Eur.
grade   puriss. p.a.
assay   ≥99.7%
form   powder
impurities   ≤0.0005% ammonium (NH4)
  ≤0.003% S-compounds (as SO4)
  ≤0.005% I red. matters (as SO2)
  ≤0.015% in water insoluble matters
pH   ≤8.6 (20 °C, 5%)
pKa (25 °C)   (1) 6.37, (2) 10.25 (carbonic acid)
solubility   H2O: 0.5 g/10 mL, clear, colorless
  water: soluble 50 g/L
density   2.16 g/mL at 25 °C (lit.)
anion traces   chloride (Cl-): ≤10 mg/kg
  phosphate (PO43-): ≤10 mg/kg
cation traces   As: 2 ppm (MHS-AAS)
  Ca: ≤100 ppm
  Cd: ≤5 ppm
  Co: ≤50 ppm
  Cu: ≤5 ppm
  Fe: ≤5 ppm
  K: ≤50 ppm
  Mg: ≤50 ppm
  Ni: ≤50 ppm
  Pb: ≤5 ppm
  Zn: ≤5 ppm
  heavy metals: ≤5 ppm (by ICP-OES)
suitability   complies for appearance of solution
SMILES string   [Na+].OC([O-])=O
InChI   1S/CH2O3.Na/c2-1(3)4;/h(H2,2,3,4);/q;+1/p-1
InChI key   UIIMBOGNXHQVGW-UHFFFAOYSA-M

Description

General description

Sodium bicarbonate is widely used as a physiological buffer. The pKa for bicarbonate ↔ carbonic acid reaction is 6.37. The pKa for bicarbonate ↔ carbonate reaction is 10.25.

Application

Sodium bicarbonate may be used to maintain 7.4pH in Iscove′s modified Dulbecco′s medium for growth of murine hybridoma cell culture. It may be employed as a component of RPMI-1640 liquid medium in a study.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
RTECS 
VZ0950000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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