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34943 Sigma-Aldrich

Dimethyl sulfoxide

puriss. p.a., dried, ≤0.02% water

Synonym: DMSO

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Properties

Related Categories Amber Glass Bottles, Analytical Reagents, Analytical Reagents for General Use, Analytical/Chromatography, C-D, Puriss p.a.,
vapor density   2.7 (vs air)
vapor pressure   0.42 mmHg ( 20 °C)
InChI Key   IAZDPXIOMUYVGZ-UHFFFAOYSA-N
grade   puriss. p.a.
assay   ≥99.9% (GC)
autoignition temp.   573 °F
quality   dried
expl. lim.   42 %, 63 °F
impurities   ≤0.0001% heavy metals (as Pb)
  ≤0.001% free acid (as H2SO4)
  ≤0.002% non-volatile matter
  ≤0.02% water
  ≤0.03% water (Karl Fischer)
refractive index   n20/D 1.479 (lit.)
bp   189 °C(lit.)
mp   16-19 °C (lit.)
density   1.10 g/mL (lit.)
cation traces   Fe: ≤1 mg/kg

Description

General description

Dimethyl sulfoxide (DMSO) is a polar solvent. DMSO activated by various electrophiles (oxalyl chloride) has been used to oxidize various alcohols (primary, secondary, allylic, benzylic, hindered and bicyclic). Carbonyl compounds are formed as reaction products. It has been proposed as an alternate solvent for methyl cellosolve for use in ninhydrin reaction, due to its high stability.

Application

Dimethyl sulfoxide (DMSO) has been used as a solvent in the high-throughput compound screening studies conducted on Mtb (Mycobacterium tuberculosis) H37Rv host cells.

Packaging

1, 6×1 L in glass bottle

Caution

Supercools easily and remelts slowly at room temperature. Solidified product can be re-liquified by warming to room temperature without detriment to the product.

Other Notes

For information on dimethyl sulfoxide miscibility, please visit the following link:
Dimethyl Sulfoxide Miscibility/Immiscibility Table

Safety & Documentation

Safety Information

WGK Germany 
1
RTECS 
PV6210000
Flash Point(F) 
188.6 °F
Flash Point(C) 
87 °C

Documents

Certificate of Analysis

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Certificate of Origin

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Protocols & Articles

Articles

Pressure-Temperature Calculator for Solvents

*Calculations provide estimated results based on Antoine's Coefficients and their associated temperature range values. Antoine's Coefficients were obtained from the National Institute of Standards an...

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Pressure-Temperature Nomograph Interactive Tool

Use the interactive controls above to simplify calculations and improve the efficiency of your distillation or evaporation requirements.
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Properties of Solvents Table

The table below presents the physical characteristics of common solvents. Easily reference or compare solvent properties like boiling point, density, and refractive index all from one list.
Keywords: Gas chromatography, Green chemistry, High performance liquid chromatography, Melting, Solvents

Peer-Reviewed Papers
15

References

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