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34998 Sigma-Aldrich

Acetonitrile

HPLC Plus, ≥99.9%

Synonym: ACN, Cyanomethane, Ethyl nitrile, Methyl cyanide

  • CAS Number 75-05-8

  • Linear Formula CH3CN

  • Molecular Weight 41.05

  •  Beilstein/REAXYS Number 741857

  •  EC Number 200-835-2

  •  MDL number MFCD00001878

  •  eCl@ss 39031501

  •  PubChem Substance ID 329755104

  •  NACRES NA.03

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Properties

Related Categories Acetonitrile and Acetonitrile Solutions, Analytical Reagents, Analytical/Chromatography, Chromatography Reagents & Solvents, HPLC Plus Grade Solvents,
Quality Level   100
grade   HPLC Plus
vapor density   1.41 (vs air)
vapor pressure   72.8 mmHg ( 20 °C)
assay   ≥99.9%
autoignition temp.   973 °F
expl. lim.   16 %
baseline drift measuring range   ≤12 mAU (210 nm)
impurities   ≤0.0001% free alkali (as NH3)
  ≤0.0002% non-volatile matter
  ≤0.001% free acid (as CH3COOH)
  ≤0.01% water (Karl Fischer)
  ≤0.5 ppb fluorescence (quinine) at 254 nm
  ≤0.5 ppb fluorescence (quinine) at 365 nm
halogenated residue   10 ng/L (as heptachlor epoxide)
refractive index   n20/D 1.344 (lit.)
bp   81-82 °C (lit.)
mp   −45 °C (lit.)
density   0.786 g/mL at 25 °C (lit.)
HPLC-gradient   ≤0.2 mAU at 254 nm
  ≤1 mAU at 210 nm
λ   H2O reference
UV absorption   λ: 195 nm Amax: ≤0.10
  λ: 200 nm Amax: ≤0.02
  λ: 228 nm Amax: ≤0.005
  λ: 235 nm Amax: ≤0.0044
  λ: 250 nm Amax: ≤0.0044
  λ: 400 nm Amax: ≤0.0044
Featured Industry   Food and Beverages
SMILES string   CC#N
InChI   1S/C2H3N/c1-2-3/h1H3
InChI key   WEVYAHXRMPXWCK-UHFFFAOYSA-N

Description

General description

Acetonitrile (MeCN) is widely employed as a solvent in various studies and has high dielectric constant (37.5). Various purification procedures to obtain different grades of acetonitrile for use in different studies (polarography, spectroscopy, etc.) have been reported by many researchers.

Application

Acetonitrile has been used to compose the gradient system for the HPLC detection of diphenylmethane diisocyanate, a polymeric degradation product.

New Quality UPLC Plus Acetonitrile is suitable for all applications including:
Mass spectrometry, HPLC, TLC, GPC, UV, IR, GC, Pesticide Residue Analysis, and RNA/DNA Synthesis and Purification.

Packaging

1, 6×1, 2.5, 4×2.5, 4, 4×4 L in glass bottle

20 L in Nowpak™

20, 50 L in Pure-Pac™ 2

200 L in Pure-Pac™ 1

View returnable container options.

200 L in Pure-Pac™ 2

Preparation Note

Product filtered through a 0.2 μm filter

Other Notes

Pure-Pac® II containers require the Micromatic MacroValve coupler for dispensing solvents, Z560723.

Important notice
• The article number 34998-4X2.5L will be discontinued. Please order the single bottle 34998-2.5L which is physically identical with the same exact specifications.
• The article number 34998-6X1L will be discontinued. Please order the single bottle 34998-1L which is physically identical with the same exact specifications.

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Legal Information

Pure-Pac is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN 1648 3 / PGII
WGK Germany 
WGK 2
RTECS 
AL7700000
Flash Point(F) 
42.8 °F - closed cup
Flash Point(C) 
6.0 °C - closed cup

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number

Certificate of Origin (COO)

Please Enter a Lot Number

Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
Who do I contact about larger solvent volume needs?
Email us at labessentials@sial.com or visit Sigma-Aldrich Fine Chemicals for development and manufacturing-scale inquiries: safcglobal@sial.com
How do I know what packaging options are available for a solvent?
The Solvent Center gives you the ability to review all the specifications associated with our solvent packaging. This includes physical dimensions, closure types, dispensing methods, UN/DOT Rating as well as solvent compatibility. Visit the Solvent Center.
Who do I contact if I need a solvent blend, which you do not carry?
Email us at labessentials@sial.com. For a complete listing of all our Solvent blends, visit the Solvent Center
The dispensing of solvents provides some challenges due to the number of container options available. What dispensing options are available for each container?
The Sigma-Aldrich Solvent Center provides numerous dispensing options for each container type. For a complete listing of all our dispensing options, visit the Solvent Center.
Which solvent grade should I be using for my application?
Sigma-Aldrich Solvent Applications Table gives a guideline to common applications and the appropriate solvent grades. Visit:Solvents
What are the options for drying solvents?
Sigma-Aldrich offers a full range of high-purity solvents with extremely low water levels specifically manufactured for moisture sensitive Organic and Biotech applications. Sigma-Aldrich also carries various drying agents such as molecular sieves, which are typically compatible with organic solvents.
What apparatus do you recommend for HPLC solvent filtration?
The Sigma-Aldrich Vacuum Filtration Assembly gives you all the components you need including: funnel top, fritted glass funnel support, filtration flask, aluminum clamp, and silicone stopper.The Acrodisc Syringe Filters offer high quality filtration for analytical samples, certified for HPLC to ensure low extractable and available in a broad range of membranes to meet sample compatibility requirements.
Can you recommend a Solvent Extractor for organics from aqueous solution?
Solvent extractors are often used for the quantitative extraction of organics from aqueous solutions and separations in immunoassays. The MIXXOR system has been applied successfully in many laboratory solvent extraction operations and is ideal for the rapid screening of alternative solvents for specific extraction problems.
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What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
My question is not addressed here, how can I contact Technical Service for assistance?
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Dispensette™ S
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Pressure-Temperature Calculator for Solvents

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Peer-Reviewed Papers
15

References

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