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360589 Sigma-Aldrich

Tetrahydrofuran

contains 250 ppm BHT as inhibitor, ACS reagent, ≥99.0%

Synonym: Butylene oxide, Oxolane, THF, Tetramethylene oxide

  • CAS Number 109-99-9

  • Empirical Formula (Hill Notation) C4H8O

  • Molecular Weight 72.11

  •  Beilstein/REAXYS Number 102391

  •  EC Number 203-726-8

  •  MDL number MFCD00005356

  •  PubChem Substance ID 329755267

  •  NACRES NA.21

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Properties

Related Categories ACS Grade, ACS Grade Solvents, ACS and Reagent Grade Solvents, Amber Glass Bottles, Carbon Steel Cans with NPT Threads,
Quality Level   200
grade   ACS reagent
vapor density   2.5 (vs air)
vapor pressure   114 mmHg ( 15 °C)
  143 mmHg ( 20 °C)
assay   ≥99.0%
autoignition temp.   610 °F
contains   250 ppm BHT as inhibitor
expl. lim.   1.8-11.8 %
impurities   ≤0.015% peroxide (as H2O2)
  ≤0.05% water
evapn. residue   ≤0.03%
color   APHA: ≤20
refractive index   n20/D 1.407 (lit.)
bp   65-67 °C (lit.)
mp   −108 °C (lit.)
solubility   water: soluble
density   0.889 g/mL at 25 °C (lit.)
SMILES string   C1CCOC1
InChI   1S/C4H8O/c1-2-4-5-3-1/h1-4H2
InChI key   WYURNTSHIVDZCO-UHFFFAOYSA-N

Description

General description

Tetrahydrofuran (THF) is a widely used organic solvent. On long term storage it forms organic peroxides. This process can be suppressed by adding butylated hydroxytoluene (BHT) as a stabilizer. BHT removes the free radicals required for the peroxide formation. The effect of THF on the biological systems has been studied.

Application

Tetrahydrofuran (THF) was used as a solvent in the following processes:
• RAFT (Reversible Addition-Fragmentation chain Transfer) polymerization of p-acetoxystyrene.
• Synthesis of di-tert-butyl-phosphinoferrocene.
• Synthesis of n-TiO2-based amphiphilic polymer brushes.
• To dissolve the LiCl from the Mg2Si nanoparticles.
It may be used in the following studies:
• As an O-donor ligand to form coordination complexes.
• As mobile phase solvent in high-performance liquid chromatography.
• As a solvent in the preparation of spin-coated poly(bisphenol A decane ether).
• Synthesis of THF doped hydrogen clathrate hydrates.

Packaging

1, 6×1, 2.5, 4, 4×4 L in glass bottle

18, 200 L in steel drum

500, 6×500 mL in glass bottle

Other Notes

Go to our Greener Alternative-2-Methyl Tetrahydrofuran - 155810

Go to our Greener Alternative-Cyclopentyl methylether - 675989

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Target organs 
Respiratory system
Supplemental Hazard Statements 
EUH018 - EUH019
RIDADR 
UN 2056 3 / PGII
WGK Germany 
WGK 1
RTECS 
LU5950000
Flash Point(F) 
-6.2 °F - closed cup
Flash Point(C) 
-21.2 °C - closed cup

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Frequently Asked Questions

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If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
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Can you recommend a Solvent Extractor for organics from aqueous solution?
Solvent extractors are often used for the quantitative extraction of organics from aqueous solutions and separations in immunoassays. The MIXXOR system has been applied successfully in many laboratory solvent extraction operations and is ideal for the rapid screening of alternative solvents for specific extraction problems.
Why do peroxides form in certain solvents and how do I test for it?
A significant number of laboratory solvents can undergo autoxidation under normal storage conditions to form unstable and potentially dangerous peroxide by-products. Molecular structure is the primary factor relating to a materials potential for hazardous peroxide formation. It is important to understand the stability of materials in use and if unclear, consult Sigma-Aldrich Technical Support, techserv@sial.com.
What are some of the preservatives used in the most common ethers and chlorinated solvents and why are they added?
Certain solvents will degrade over time requiring special handling and storage considerations. In addition, the products of certain degradation processes pose a potential safety risk if present at sufficiently high levels. For these types of materials, small amounts of stabilizing chemicals are added to slow down or stop material degradation.
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Protocols & Articles

Articles

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Peer-Reviewed Papers
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References

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