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41640 Sigma-Aldrich

Dimethyl sulfoxide

puriss. p.a., ACS reagent, ≥99.9% (GC)

Synonym: DMSO

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Properties

Related Categories Analytical Reagents, Analytical Reagents for General Use, Analytical/Chromatography, C-D, Puriss p.a. ACS, Dimethyl Sulfoxide (DMSO),
Quality Level   PREMIUM
grade   ACS reagent
vapor density   2.7 (vs air)
vapor pressure   0.42 mmHg ( 20 °C)
InChI Key   IAZDPXIOMUYVGZ-UHFFFAOYSA-N
grade   puriss. p.a.
assay   ≥99.9% (GC)
autoignition temp.   573 °F
expl. lim.   42 %, 63 °F
impurities   ≤0.001% free acid (as CH3COOH)
  ≤0.1% water
evapn. residue   ≤0.005%
refractive index   n20/D 1.479 (lit.)
  n20/D 1.479
bp   189 °C(lit.)
mp   16-19 °C (lit.)
  18-20 °C
density   1.10 g/mL (lit.)
cation traces   Al: ≤0.5 mg/kg
  Ba: ≤0.1 mg/kg
  Bi: ≤0.1 mg/kg
  Ca: ≤0.5 mg/kg
  Cd: ≤0.05 mg/kg
  Co: ≤0.02 mg/kg
  Cr: ≤0.02 mg/kg
  Cu: ≤0.02 mg/kg
  Fe: ≤0.5 mg/kg
  K: ≤0.5 mg/kg
  Li: ≤0.1 mg/kg
  Mg: ≤0.1 mg/kg
  Mn: ≤0.02 mg/kg
  Mo: ≤0.1 mg/kg
  Na: ≤1 mg/kg
  Ni: ≤0.5 mg/kg
  Pb: ≤0.1 mg/kg
  Sr: ≤0.1 mg/kg
  Zn: ≤0.1 mg/kg

Description

General description

Dimethyl sulfoxide (DMSO) is a polar solvent. DMSO activated by electrophile (oxalyl chloride) has been used to oxidize various alcohols (primary, secondary, allylic, benzylic, hindered and bicyclic). Carbonyl compounds are formed as reaction products. It has been proposed as an alternate solvent for methyl cellosolve for use in ninhydrin reaction, due to its high stability.

Caution

Supercools easily and remelts slowly at room temperature. Solidified product can be re-liquified by warming to room temperature without detriment to the product.

Other Notes

For information on dimethyl sulfoxide miscibility, please visit the following link:
Dimethyl Sulfoxide Miscibility/Immiscibility Table

Use as reagent in synthesis

Safety & Documentation

Safety Information

WGK Germany 
1
RTECS 
PV6210000
Flash Point(F) 
188.6 °F
Flash Point(C) 
87 °C

Documents

Certificate of Analysis

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Protocols & Articles

Articles

Pressure-Temperature Calculator for Solvents

*Calculations provide estimated results based on Antoine's Coefficients and their associated temperature range values. Antoine's Coefficients were obtained from the National Institute of Standards an...

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Properties of Solvents Table

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Peer-Reviewed Papers
15

References

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