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439169 Sigma-Aldrich

Ethyl acetate

for HPLC, ≥99.8%

Synonym: EtOAc

  • CAS Number 141-78-6

  • Linear Formula CH3COOC2H5

  • Molecular Weight 88.11

  •  Beilstein/REAXYS Number 506104

  •  EC Number 205-500-4

  •  MDL number MFCD00009171

  •  PubChem Substance ID 329756423

  •  NACRES NA.21

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Properties

Related Categories Analytical Reagents, Analytical/Chromatography, Chromatography Reagents & Solvents, Ethyl Acetate, HPLC,
Quality Level   100
grade   for HPLC
vapor density   3 (20 °C, vs air)
vapor pressure   73 mmHg ( 20 °C)
assay   ≥99.8%
form   liquid
autoignition temp.   801 °F
expl. lim.   2.2-11.5 %, 38 °F
application(s)   GC/MS: suitable
  HPLC: suitable
impurities   <0.050% water
evapn. residue   <0.0003%
refractive index   n20/D 1.3720 (lit.)
bp   76.5-77.5 °C (lit.)
mp   −84 °C (lit.)
solubility   alcohol: soluble(lit.)
  chloroform: soluble(lit.)
density   0.902 g/mL at 25 °C (lit.)
λ   H2O reference
UV absorption   λ: 254 nm Amax: 1.00
  λ: 263 nm Amax: 0.05
  λ: 275-400 nm Amax: 0.01
Featured Industry   Food and Beverages
SMILES string   CCOC(C)=O
InChI   1S/C4H8O2/c1-3-6-4(2)5/h3H2,1-2H3
InChI key   XEKOWRVHYACXOJ-UHFFFAOYSA-N

Description

General description

Ethyl acetate (EA), a carboxylate ester, is bio-friendly organic solvent with a wide range of industrial applications. Its synthesis by reactive distillation and by acceptorless dehydrogenative dimerization of ethanol has been explored. Its ability as an acyl acceptor in the immobilized lipase-mediated preparation of biodiesel from crude vegetable oils has been examined. The complete degradation of ethyl acetate to CO2 using manganese octahedral molecular sieve (OMS-2) has been investigated. EA is an effective alternate solvent of diethyl ether, employed for the concentration of eggs, larvae, and cysts in fecal specimens during the Formalin-ether sedimentation technique. Acetaldehyde is reaction intermediate formed during the oxidative combustion of ethanol and ethyl acetate in the presence of copper oxide embedded on Ce-doped titania surface.

Application

Ethyl acetate may be used in the following studies:
• As solvent for the isolation of Rose hip (Rosa canina L., Rosaceae) powder, via sonication.
• As solvent for the abstraction of volatile thiols from wine for their quantitative estimation by gas chromatography/mass spectrometry (GC-MS).
• Preparation of thin films of TiO2 (titanium dioxide) on glass.
• As an extraction medium in the multi-residue analysis of pesticide residues in fruit and vegetables.
• Acetylation of primary amines to form amides in the presence of dimethyltin(IV) acetic acid distannoxane.

Packaging

2×10, 20 L in Nowpak™

20 L in Pure-Pac™ 2

4, 4×4 L in PVC-coated bottle

50 L in composite drum

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Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
Target organs 
Central nervous system
RIDADR 
UN1173 - class 3 - PG 2 - Ethyl acetate
WGK Germany 
WGK 1
RTECS 
AH5425000
Flash Point(F) 
24.8 °F
Flash Point(C) 
-4 °C

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Pressure-Temperature Calculator for Solvents

*Calculations provide estimated results based on Antoine's Coefficients and their associated temperature range values. Antoine's Coefficients were obtained from the National Institute of Standards an...

Peer-Reviewed Papers
15

References

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