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494496 Sigma-Aldrich

1-Methyl-2-pyrrolidinone

biotech. grade, ≥99.7%

Synonym: 1-Methyl-2-pyrrolidone, N-Methyl-2-pyrrolidone, NMP

  • CAS Number 872-50-4

  • Empirical Formula (Hill Notation) C5H9NO

  • Molecular Weight 99.13

  •  Beilstein/REAXYS Number 106420

  •  EC Number 212-828-1

  •  MDL number MFCD00003193

  •  PubChem Substance ID 329757456

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Properties

Related Categories Amber Glass Bottles, Biotech, Biotech Solvents, Returnable Containers, Solvent Bottles,
Quality Level   100
grade   biotech. grade
  for peptide synthesis
vapor density   3.4 (vs air)
vapor pressure   0.29 mmHg ( 20 °C)
  0.99 mmHg ( 40 °C)
assay   ≥99.7%
form   liquid
autoignition temp.   518 °F
expl. lim.   9.5 %
application(s)   peptide synthesis: suitable
impurities   ≤0.005% water
  ≤0.01% free amines (CH3NH2)
color   APHA: ≤20
refractive index   n20/D 1.47 (lit.)
pH   7.7-10.0 (20 °C, 100 g/L)
bp   202 °C (lit.)
  81-82 °C/10 mmHg (lit.)
mp   −24 °C (lit.)
solubility   acetone: miscible(lit.)
  alcohol: miscible(lit.)
  chloroform: miscible(lit.)
  ethyl acetate: miscible(lit.)
  water: miscible(lit.)
density   1.028 g/mL at 25 °C (lit.)
λ   H2O reference
UV absorption   λ: 285 nm Amax: 1.00
  λ: 300 nm Amax: 0.50
  λ: 325 nm Amax: 0.10
  λ: 350-400 nm Amax: 0.01
SMILES string   CN1CCCC1=O
InChI   1S/C5H9NO/c1-6-4-2-3-5(6)7/h2-4H2,1H3
InChI key   SECXISVLQFMRJM-UHFFFAOYSA-N

Description

General description

N-Methyl-2-pyrrolidinone (N-methylpyrrolidone, NMP) is a polar cyclic organic solvent. A study on the impact of NMP on Saccharomyces cerevisiae revealed that it induced aneuploidy. Characteristic properties of NMP include low viscosity, excellent dissolving power and enhanced demulsifying property. It is a better alternative to phenol in selectively treating lube feedstock. The behavior of fullerene-C60 in NMP solution has been examined based on electronic absorption and photoluminescence spectral data. A solution of sodium borohydride (NaBH4) in NMP showed increased reactivity towards debromination of alkyl bromide. The enhanced selectivity of NMP-ethylene glycol solvent mixture for aromatic hydrocarbon extraction has been analyzed by gas chromatography.

Packaging

1, 2, 4×2 L in Sure/Seal™

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Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Target organs 
Respiratory system
WGK Germany 
WGK 1
RTECS 
UY5790000
Flash Point(F) 
195.8 °F - closed cup
Flash Point(C) 
91 °C - closed cup

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Pressure-Temperature Calculator for Solvents

*Calculations provide estimated results based on Antoine's Coefficients and their associated temperature range values. Antoine's Coefficients were obtained from the National Institute of Standards an...

Peer-Reviewed Papers
15

References

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