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571261 Sigma-Aldrich

Piperidine

biotech. grade, ≥99.5%

Synonym: Hexahydropyridine

  • CAS Number 110-89-4

  • Empirical Formula (Hill Notation) C5H11N

  • Molecular Weight 85.15

  •  Beilstein/REAXYS Number 102438

  •  EC Number 203-813-0

  •  MDL number MFCD00005979

  •  PubChem Substance ID 329758271

  •  NACRES NA.21

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Properties

Related Categories Amber Glass Bottles, Biotech, Solvent Bottles, Solvent Packaging Options, Solvents,
grade   biotech. grade
vapor density   3 (vs air)
vapor pressure   23 mmHg ( 20 °C)
assay   ≥99.5%
impurities   <0.3% water
refractive index   n20/D 1.452 (lit.)
bp   106 °C (lit.)
  106 °C
mp   −13 °C (lit.)
solubility   organic solvents: soluble(lit.)
  water: miscible(lit.)
density   0.862 g/mL at 20 °C (lit.)
λ   1 cm path, H2O reference
UV absorption   λ: 290 Amax: <1.000
  λ: 370 Amax: <0.050
SMILES string   C1CCNCC1
InChI   1S/C5H11N/c1-2-4-6-5-3-1/h6H,1-5H2
InChI key   NQRYJNQNLNOLGT-UHFFFAOYSA-N

Description

General description

Piperidine, a heterocyclic cyclohexane is a volatile secondary amine. Maxam-Gilbert chemical method, a DNA sequencing technology employs piperidine to rupture DNA strands at damaged base site. Its crystal structure analyzed at 150K shows hydrogen bonding between NH groups. Piperidine ring forms a part of many naturally occuring alkaloids. It is prepared on an industrial scale by the hydrogenation of pyridine in the presence of nickel catalyst. The 1H NMR spectrum of piperidine has been recorded.

Application

Fits Applied Biosystems 431 and 433A peptide synthesizers.

Piperidine has been used in combination with DMF (dimethylformamide) for the removal of Fmoc (fluorenylmethyloxycarbonyl) group from the N-terminal amino group during peptide synthesis.

Packaging

200, 450 mL in glass bottle

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN 2401 3(8) / PGI
WGK Germany 
WGK 1
RTECS 
TM3500000
Flash Point(F) 
60.8 °F - closed cup
Flash Point(C) 
16 °C - closed cup

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Pressure-Temperature Calculator for Solvents

*Calculations provide estimated results based on Antoine's Coefficients and their associated temperature range values. Antoine's Coefficients were obtained from the National Institute of Standards an...

Peer-Reviewed Papers
15

References

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