650447 Sigma-Aldrich


HPLC Plus, for HPLC, GC, and residue analysis, 99.9%

Synonym: sec-Propyl alcohol, IPA, Isopropanol, Isopropyl alcohol, isopropanol

  • CAS Number 67-63-0

  • Linear Formula (CH3)2CHOH

  • Molecular Weight 60.10

  •  Beilstein/REAXYS Number 635639

  •  EC Number 200-661-7

  •  MDL number MFCD00011674

  •  PubChem Substance ID 329760020

  •  NACRES NA.05



Related Categories 2-Propanol (Isopropanol), Amber Glass Bottles, Analytical Reagents, Analytical/Chromatography, Chromatography Reagents,
Quality Level   100
grade   HPLC Plus
  for GC
  for residue analysis
vapor density   2.1 (vs air)
vapor pressure   33 mmHg ( 20 °C)
  44 mmHg ( 25 °C)
assay   99.9%
form   liquid
autoignition temp.   750 °F
expl. lim.   2.0-12.7 %, 93 °C
application(s)   HPLC: suitable
  HPLC: suitable
impurities   ≤0.02% water
  ≤0.5 ppb Fluorescence (quinine) (365 nm)
evapn. residue   ≤0.0001%
halogenated residue   ≤10 ng/L (as heptachlor epoxide)
refractive index   n20/D 1.377 (lit.)
pH   7.0 (20 °C)
bp   82 °C (lit.)
mp   −89.5 °C (lit.)
solubility   water: soluble
density   0.785 g/mL at 25 °C (lit.)
λ   H2O reference
UV absorption   λ: 245 nm Amax: ≤1.0
  λ: 250 nm Amax: ≤0.30
  λ: 275-400 nm Amax: ≤0.005
Featured Industry   Food and Beverages
SMILES string   CC(C)O
InChI   1S/C3H8O/c1-3(2)4/h3-4H,1-2H3


General description

2-Propanol (Isopropanol) is a secondary alcohol. It has been tested as a substitute of the fuel for use in various fuel cells. CuO powder dissolved in 2-propanol has been used for the laser ablation assisted synthesis of Cu colloids. Suspension of 2-propanol with Zn(NO3)2 has been employed for the fabrication of titanium dioxide-coated stainless steel (P25-TiO2/SS) photoanode coated with uniformly thick layer of P25-TiO2. This photoanode was used for the electrochemical photocatalytic (ECPC) degradation process. Preparation of methyl isobutyl ketone (MIBK) using 2-propanol as the precursor has been reported with yield as high as 25%. Solubility of benzoic acid has been investigated in 2-propanol by gravimetric method in the temperature range, 277-346K.


2-Propanol (Isopropanol) may be used in the following processes:
• Isolation and quantitative determination of carotenes and xanthophylls from Capsicum annum pericarp extracts by HPLC.
• As solvent in the dissolution of Pt and TiO2 precursors, for the fabrication of Pt-TiO2/Ti electrodes.
• As a solvent in the synthesis of di- and trisubstituted ortho biaryls by Suzuki-Miyaura cross-coupling reaction.
• As an alternate solvent to benzene in the analysis of total carbonyl compounds in heated and frying oils.
• As a reaction medium in the preparation of cyclic ureas by reacting CO2 with diamines in the presence of pure cerium oxide (CeO2).

Suitable for HPLC, spectrophotometry, environmental testing


1, 6×1, 4×2, 2.5, 4, 4×4 L in glass bottle

20 L in Nowpak™ II

50 L in Pure-Pac™ 2

View returnable container options.

56 L in Pure-Pac™ 1

Preparation Note

Product filtered through a 0.2 μm filter

Other Notes

Pure-Pac® II containers require the Micromatic MacroValve coupler for dispensing solvents, Z560723.

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Legal Information

Pure-Pac is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Signal word 
Hazard statements 
Target organs 
Central nervous system
UN1219 - class 3 - PG 2 - Isopropanol
WGK Germany 
Flash Point(F) 
53.6 °F - closed cup
Flash Point(C) 
12.0 °C - closed cup


Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles


Pressure-Temperature Calculator for Solvents

*Calculations provide estimated results based on Antoine's Coefficients and their associated temperature range values. Antoine's Coefficients were obtained from the National Institute of Standards an...

Peer-Reviewed Papers


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