650447 Sigma-Aldrich


HPLC Plus, for HPLC, GC, and residue analysis, 99.9%

Synonym: sec-Propyl alcohol, IPA, Isopropanol, Isopropyl alcohol, isopropanol



Related Categories 2-Propanol (Isopropanol), Amber Glass Bottles, Analytical Reagents, Analytical/Chromatography, Chromatography Reagents & Solvents,
grade   HPLC Plus
  for GC
  for HPLC
  for residue analysis
vapor density   2.1 (vs air)
vapor pressure   33 mmHg ( 20 °C)
  44 mmHg ( 25 °C)
assay   99.9%
autoignition temp.   750 °F
expl. lim.   2 %
impurities   ≤0.02% water
  ≤0.5 ppb Fluorescence (quinine) (365 nm)
evapn. residue   ≤0.0001%
halogenated residue   ≤10 ng/L (as heptachlor epoxide)
refractive index   n20/D 1.377 (lit.)
bp   82 °C (lit.)
mp   −89.5 °C (lit.)
solubility   water: soluble
density   0.785 g/mL at 25 °C (lit.)
λ   H2O reference
UV absorption   λ: 245 nm Amax: ≤1.0
  λ: 250 nm Amax: ≤0.30
  λ: 275-400 nm Amax: ≤0.005
Featured Industry   Food and Beverages


General description

2-Propanol (Isopropanol) is a secondary alcohol. It has been tested as a substitute of the fuel for use in various fuel cells. CuO powder dissolved in 2-propanol has been used for the laser ablation assisted synthesis of Cu colloids. Suspension of 2-propanol with Zn(NO3)2 has been employed for the fabrication of titanium dioxide-coated stainless steel (P25-TiO2/SS) photoanode coated with uniformly thick layer of P25-TiO2. This photoanode was used for the electrochemical photocatalytic (ECPC) degradation process. Preparation of methyl isobutyl ketone (MIBK) using 2-propanol as the precursor has been reported with yield as high as 25%. Solubility of benzoic acid has been investigated in 2-propanol by gravimetric method in the temperature range, 277-346K.


2-Propanol (Isopropanol) may be used in the following processes:
• Isolation and quantitative determination of carotenes and xanthophylls from Capsicum annum pericarp extracts by HPLC.
• As solvent in the dissolution of Pt and TiO2 precursors, for the fabrication of Pt-TiO2/Ti electrodes.
• As a solvent in the synthesis of di- and trisubstituted ortho biaryls by Suzuki-Miyaura cross-coupling reaction.
• As an alternate solvent to benzene in the analysis of total carbonyl compounds in heated and frying oils.
• As a reaction medium in the preparation of cyclic ureas by reacting CO2 with diamines in the presence of pure cerium oxide (CeO2).

Suitable for HPLC, spectrophotometry, environmental testing


1, 6×1, 4×2, 2.5, 4, 4×4 L in glass bottle

20 L in Nowpak™ II

50 L in Pure-Pac™ 2

View returnable container options.

56 L in Pure-Pac™ 1

Preparation Note

Product filtered through a 0.2 μm filter

Other Notes

Pure-Pac® II containers require the Micromatic MacroValve coupler for dispensing solvents, Z560723.

Recommended products

Discover LiChropur reagents ideal for HPLC or LC-MS analysis

Legal Information

Pure-Pac is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Signal word 
Hazard statements 
Precautionary statements 
UN1219 - class 3 - PG 2 - Isopropanol
WGK Germany 
Flash Point(F) 
53.6 °F
Flash Point(C) 
12 °C


Certificate of Analysis


Certificate of Origin


Dispensette™ S
Protocols & Articles


Pressure-Temperature Calculator for Solvents

*Calculations provide estimated results based on Antoine's Coefficients and their associated temperature range values. Antoine's Coefficients were obtained from the National Institute of Standards an...

Related Content

Pressure-Temperature Nomograph Interactive Tool

Use the interactive controls above to simplify calculations and improve the efficiency of your distillation or evaporation requirements.
Keywords: Evaporation, Vaporization

Properties of Solvents Table

The table below presents the physical characteristics of common solvents. Easily reference or compare solvent properties like boiling point, density, and refractive index all from one list.
Keywords: Gas chromatography, Green chemistry, High performance liquid chromatography, Melting, Solvents

Peer-Reviewed Papers


Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?