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676764 Sigma-Aldrich

Tetrahydrofuran

ACS reagent, ≥99.0%, contains 250 ppm BHT as inhibitor

Synonym: Butylene oxide, Oxolane, Tetramethylene oxide

  • CAS Number 109-99-9

  • Empirical Formula (Hill Notation) C4H8O

  • Molecular Weight 72.11

  •  Beilstein/REAXYS Number 102391

  •  EC Number 203-726-8

  •  MDL number MFCD00005356

  •  PubChem Substance ID 329760651

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Properties

Related Categories Aluminum Bottles, Solvent Bottles, Solvent Packaging Options, Solvents
Quality Level   200
grade   ACS reagent
vapor density   2.5 (vs air)
vapor pressure   114 mmHg ( 15 °C)
  143 mmHg ( 20 °C)
assay   ≥99.0%
form   liquid
autoignition temp.   610 °F
contains   250 ppm BHT as inhibitor
expl. lim.   1.8-11.8 %
application(s)   HPLC: suitable
impurities   ≤0.015% peroxide (as H2O2)
  ≤0.05% water
evapn. residue   ≤0.03%
color   APHA: ≤20
refractive index   n20/D 1.407 (lit.)
pH   ~7
bp   65-67 °C (lit.)
mp   −108 °C (lit.)
density   0.889 g/mL at 25 °C (lit.)
SMILES string   C1CCOC1
InChI   1S/C4H8O/c1-2-4-5-3-1/h1-4H2
InChI key   WYURNTSHIVDZCO-UHFFFAOYSA-N

Description

General description

Tetrahydrofuran (THF) is a saturated cyclic ether with a potential use as a biofuel. Its combustion studies have been reported. Reports suggest it is a better promoter than 1,3 dioxolane for CO2-hydrate formation. On long term storage it forms organic peroxides. This process can be suppressed by adding butylated hydroxytoluene (BHT) as a stabilizer. BHT removes the free radicals required for the peroxide formation. The effect of THF on the biological systems has been studied.

Application

Tetrahydrofuran may be used as a solvent in the following processes:
• Formation of diacetylinic polymers.
• Reversible Addition-Fragmentation chain Transfer (RAFT) polymerization of p-acetoxystyrene.
• Synthesis of di-tert-butyl-Phosphinoferrocene.
It may be used in the following processes:
• As mobile phase solvent in high-performance liquid chromatography.
• As a solvent in the preparation of spin-coated poly(bisphenol A decane ether).
• Formation of butyrolactone (BTL) by green oxidation method.
• As a solvent for lignin depolymerization to isolate phenolic monomer.

Packaging

1, 4, 4×4 L in aluminum bottle

Other Notes

Go to our Greener Alternative-2-Methyl Tetrahydrofuran - 155810

Go to our Greener Alternative-Cyclopentyl methylether - 675989

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Supplemental Hazard Statements 
EUH018 - EUH019
RIDADR 
UN 2056 3 / PGII
WGK Germany 
WGK 1
RTECS 
LU5950000
Flash Point(F) 
-6.2 °F - closed cup
Flash Point(C) 
-21.2 °C - closed cup
Protocols & Articles

Articles

Pressure-Temperature Calculator for Solvents

*Calculations provide estimated results based on Antoine's Coefficients and their associated temperature range values. Antoine's Coefficients were obtained from the National Institute of Standards an...

Peer-Reviewed Papers
15

References

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