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91707 Sigma-Aldrich

Trifluoroacetic acid

puriss. p.a., for HPLC, ≥99.0% (GC)

Synonym: TFA

  • CAS Number 76-05-1

  • Linear Formula CF3COOH

  • Molecular Weight 114.02

  •  Beilstein/REAXYS Number 742035

  •  EC Number 200-929-3

  •  MDL number MFCD00004169

  •  PubChem Substance ID 329770068

  •  NACRES NA.21

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Properties

Related Categories Acids, Acids & Bases, Chemical Synthesis, Organic Acids, Synthetic Reagents More...
Quality Level   200
grade   for HPLC
vapor density   3.9 (vs air)
vapor pressure   97.5 mmHg ( 20 °C)
grade   puriss. p.a.
assay   ≥99.0% (GC)
form   liquid
application(s)   LC/MS: suitable
impurities   ≤0.05% water
refractive index   n20/D 1.3 (lit.)
pH   1 (20 °C, 1  g/L)
bp   72.4 °C (lit.)
mp   −15.4 °C (lit.)
solubility   water: soluble
density   1.489 g/mL at 20 °C (lit.)
λ   1 cm path, H2O reference
UV absorption   λ: 260 nm Amax: 0.9
  λ: 270 nm Amax: 0.1
  λ: 280 nm Amax: 0.05
  λ: 290 nm Amax: 0.04
  λ: 300 nm Amax: 0.03
  λ: 320 nm Amax: 0.025
suitability   corresponds to standard for RP gradient test
SMILES string   OC(C(F)(F)F)=O
InChI   1S/C2HF3O2/c3-2(4,5)1(6)7/h(H,6,7)
InChI key   DTQVDTLACAAQTR-UHFFFAOYSA-N

Description

General description

Trifluoroacetic acid (TFA) is a fluorinated acetic acid. It is widely used as trifluoromethylating reagent for trifluoromethylation of aromatic compounds.

Application

Trifluoroacetic acid (TFA) may be used in the following studies:
• Preparation of TFA reagent for the estimation of serum vitamin A.
• To compose the binary solvent system for the isolation of large denatured peptides by reverse phase high performance liquid chromatography.
• A mobile-phase additive for liquid chromatography-mass spectrometry (LC-MS) analysis.
• Preparation of artemisinin under optimized reaction conditions.

Packaging

package with 10x1mL

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Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN 2699 8 / PGI
WGK Germany 
WGK 2
RTECS 
AJ9625000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles

Protocols

Fmoc SPPS Protocols for Cysteine Peptides

Peptides containing Cys can exist in either reduced (sulfhydryl) or oxidized inter/intra chain disulfide bonded forms. The synthesis of peptides containing Cys, therefore, presents special challenges...
Keywords: Alkylations, Asymmetric synthesis, Buffers, Centrifugation, Coupling reactions, Cyclizations, Eliminations, Evaporation, Filtration, High performance liquid chromatography, Hormones, Iodinations, Oxidations, Peptide synthesis, Purification, Racemizations, Rearrangements, Reductions, Solid phase peptide synthesis, Solvents, Thiolysis

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Peer-Reviewed Papers
15

References

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