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05288 Sigma-Aldrich

K-252a

from Nocardiopsis sp.

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Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics G-M, Biochemicals and Reagents, Cell Biology,
biological source   Nocardiopsis sp.
InChI Key   KOZFSFOOLUUIGY-SOLYNIJKSA-N
Mode of action   enzyme | inhibits
antibiotic activity spectrum   viruses
storage temp.   −20°C
Gene Information   human ... NTRK1(4914)
rat ... Prkca(24680)

Description

Biochem/physiol Actions

Potent inhibitor of various protein kinases including protein kinase A, C, and G. It is is reported to selectively inhibit the actions of nerve growth factor (NGF) on PC1 2 cells and has been shown to inhibit smooth muscle myosin light chain kinase .

Application

K-252a is used to inhibit protein kinases involved in cell signaling processes, including CaM kinase; phosphorylase kinase, serine/threonine kinases, Trk. It is used to inhibit the actions of nerve growth factor (NGF) on PC1 2 cells and to inhibit smooth muscle myosin light chain kinase .

Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

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Description

Add to Cart

K1639 K-252a, from Nonomuraea longicatena, ≥98% (HPLC)
K2015 K-252a, Ready Made Solution, from Nonomuraea longicatena, >98%

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