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11039 Sigma-Aldrich

L-Arginine monohydrochloride

BioUltra, ≥99.5% (AT)

Synonym: (S)-(+)-2-Amino-5-[(aminoiminomethyl)amino]pentanoic acid monohydrochloride, (S)-(+)-Arginine hydrochloride

  • CAS Number 1119-34-2

  • Empirical Formula (Hill Notation) C6H14N4O2 · HCl

  • Molecular Weight 210.66

  •  Beilstein/REAXYS Number 3631658

  •  EC Number 214-275-1

  •  MDL number MFCD00064550

  •  PubChem Substance ID 57646880

  •  NACRES NA.26

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Properties

Related Categories Amino Acids, BioUltra, Biochemicals and Reagents More...
Quality Level   200
product line   BioUltra
assay   ≥99.5% (AT)
form   powder or crystals
optical activity   [α]20/D +22.0±0.5°, c = 5% in 5 M HCl
application(s)   ligand binding assay: suitable
impurities   insoluble matter, passes filter test
  ≤0.3% foreign amino acids
ign. residue   ≤0.05%
loss   ≤0.05% loss on drying, 20 °C (HV)
color   colorless
pH   5.5-7.0 (25 °C, 1 M in H2O)
mp   220-230 °C
solubility   H2O: 1 M at 20 °C, clear, colorless
density   1.42 g/cm3 at 20 °C
anion traces   sulfate (SO42-): ≤50 mg/kg
cation traces   Al: ≤5 mg/kg
  As: ≤0.1 mg/kg
  Ba: ≤5 mg/kg
  Bi: ≤5 mg/kg
  Ca: ≤10 mg/kg
  Cd: ≤5 mg/kg
  Co: ≤5 mg/kg
  Cr: ≤5 mg/kg
  Cu: ≤5 mg/kg
  Fe: ≤5 mg/kg
  K: ≤50 mg/kg
  Li: ≤5 mg/kg
  Mg: ≤5 mg/kg
  Mn: ≤5 mg/kg
  Mo: ≤5 mg/kg
  Na: ≤50 mg/kg
  Ni: ≤5 mg/kg
  Pb: ≤5 mg/kg
  Sr: ≤5 mg/kg
  Zn: ≤5 mg/kg
λ   1 M in H2O
UV absorption   λ: 260 nm Amax: ≤0.2
  λ: 280 nm Amax: ≤0.1
SMILES string   Cl[H].N[C@@H](CCCNC(N)=N)C(O)=O
InChI   1S/C6H14N4O2.ClH/c7-4(5(11)12)2-1-3-10-6(8)9;/h4H,1-3,7H2,(H,11,12)(H4,8,9,10);1H/t4-;/m0./s1
InChI key   KWTQSFXGGICVPE-WCCKRBBISA-N

Description

Application

L-Arginine monohydrochloride has been used to study the reversal of the inhibitory effect of L-NG0-nitroarginine on non-cholinergic relaxations. It has also been used as a dietary supplement to study its effect on endothelium-dependent vasodilation.

Biochem/physiol Actions

L-Arginine is considered as a semi essential amino acid. In most mammals including humans, L-Arginine synthesis occurs through intestinal-renal axis, from glutamine, glutamate and proline. Abnormal levels of L-Arginine is associated with the development of kidney and cardiovascular disease. L-arginine is found to decrease fat mass and visceral adiposity.

Substrate of nitric oxide synthase, which is converted to citrulline and nitric oxide (NO). Induces insulin release by a nitric oxide-dependent mechanism.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
RTECS 
CF1995500
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

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Peer-Reviewed Papers
15

References

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