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110M-1 Sigma-Aldrich

CD10 (56C6) Mouse Monoclonal Antibody

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Properties

Related Categories Alphabetical Index, Antibodies, CD0-CDC, Cell Marque Antibodies, Hematopathology,
Quality Level   GMP-IVD
biological source   mouse
antibody form   culture supernatant
antibody product type   primary antibodies
clone   56C6, monoclonal
description   For In Vitro Diagnostic Use in Select Regions (See Chart)
form   buffered aqueous solution
species reactivity   human
packaging   vial of 0.1 mL concentrate (110M-14)
  vial of 0.5 mL concentrate (110M-15)
  bottle of 1.0 mL predilute (110M-17)
  vial of 1.0 mL concentrate (110M-16)
  bottle of 7.0 mL predilute (110M-18)
mfr. no.   Cell Marque
concentration   0.01-1 μg/mL (predilute)
  1-5 μg/mL (concentrate)
application(s)   immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:10-1:50
isotype   IgG1
conjugate   unconjugated
control   kidney, tonsil
shipped in   wet ice
storage temp.   2-8°C
visualization   cytoplasmic, membranous

Description

General description

CD10, common acute lymphoblastic leukemia antigen, is expressed in early lymphoid progenitors and normal germinal center cells. The staining pattern is cytoplasmic. As with BCL6, an antibody against CD10 is used to identify B cells of germinal center origin and their neoplastic counterparts, such as follicular lymphoma. It can be used in combination with other stains such as BCL6, MUM1, FOXP1, GCET, and LMO2 to identify diffuse large B cell lymphoma with germinal center signature. This antibody almost always labels precursor B lymphoblastic leukemia/lymphoma and Burkitt lymphoma, but much less frequently labels precursor T lymphoblastic leukemia/lymphoma.CD10 is expressed by a subset of T follicular helper cells, although not by normal peripheral T cells. CD10 expression has been found in angioimmunoblastic T cell lymphoma (AITL). The expression is highly specific for AITL because other nodal peripheral T cell lymphomas only rarely express this antigen. CD10 expression has been reported in a variety of non-hematolymphoid tissues and their neoplastic counterparts; in particular, renal cell carcinoma, endometrial stromal sarcoma, and hepatocellular carcinoma, among other malignant tumors. The clone 56C6 shows higher staining intensity in non-hematolymphoid than hematolymphoid neoplasms.

Linkage

CD10 Positive Control Slides, Product No. 110S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Preparation Note

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Quality


IVD

IVD

IVD

RUO

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

Protocols & Articles

Articles

Antibody Basics

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Peer-Reviewed Papers
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References

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110S CD10 Positive Control Slides, immunohistochemistry (formalin-fixed, paraffin-embedded sections) 

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