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  • 118R-1 - CD38 (SP149) Rabbit Monoclonal Antibody

118R-1 Sigma-Aldrich

CD38 (SP149) Rabbit Monoclonal Antibody

  •  NACRES NA.41



Related Categories Alphabetical Index, Antibodies, CD0-CDC, Cell Marque Antibodies, Hematopathology,
conjugate   unconjugated
clone   SP149, monoclonal
biological source   rabbit
application(s)   immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
species reactivity   human
form   buffered aqueous solution
shipped in   wet ice
storage temp.   2-8°C
packaging   vial of 0.1 mL concentrate (118R-14)
  vial of 0.5 mL concentrate (118R-15)
  bottle of 1.0 mL predilute (118R-17)
  vial of 1.0 mL concentrate (118R-16)
  bottle of 7.0 mL predilute (118R-18)
antibody form   culture supernatant
isotype   IgG
Quality Level   100
antibody product type   primary antibodies
description   For In Vitro Diagnostic Use in Select Regions (See Chart)
mfr. no.   Cell Marque
concentration   0.1-5 μg/mL (predilute)
  10-500 μg/mL (concentrate)
control   bone marrow, lymph node, plasma cell myeloma
visualization   cytoplasmic


General description

Anti-CD38 is a very useful immunostaining marker, when combined with antibodies against CD138, MUM1, and EMA in a panel, for the diagnosis of immunodeficiency-related lymphomas, which usually include plasmablastic lymphoma, primary effusion lymphoma, and large B-cell lymphoma arising in HHV8-associated multicentric Castleman disease. Such immunodeficiency-related lymphomas are either pan-B-cell-marker negative or only weakly positive. Furthermore, IHC detection of plasma cells by anti-CD38 immunohistochemical staining on a bone marrow trephine biopsy is necessary to obtain the accurate counts of malignant plasma cells needed to make a definitive diagnosis given that malignant plasma cell counts are difficult to obtain due to sub-optimal bone marrow aspiration, frequent focal distribution of myeloma cells in bone marrow, and loss of neoplastic plasma cells when manual processing is being performed. Recent studies have demonstrated that anti-CD38, combined with anti-CD44 (negative) and/or anti-TCL1 (positive), is useful in identifying the cases of large B-cell lymphoma with cMYC gene rearrangement (respective sensitivity of 82% and 77%; respective specificity of 100% and 100%). Therefore, anti-CD38 is very important in differential diagnosis of anti-CD20-positive, anti-TdT/anti-cyclin D1-negative diffuse large-to-medium-sized B-cell neoplasms, including diffuse large B-cell lymphoma, Burkitt lymphoma, and B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and Burkitt lymphoma.

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC







CD38 Positive Control Slides, Product No. 118S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Preparation Note

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Other Notes

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Safety & Documentation

Safety Information

NONH for all modes of transport


Certificate of Analysis (COA)

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Protocols & Articles


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118S CD38 Positive Control Slides, suitable for immunohistochemistry (formalin-fixed, paraffin-embedded sections) 

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