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156R-9 Sigma-Aldrich

CD56 (MRQ-42) Rabbit Monoclonal Antibody

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Properties

Related Categories Alphabetical Index, Anatomic Pathology, Antibodies, CD0-CDC, Cell Marque Antibodies,
Quality Level   GMP-IVD
biological source   rabbit
antibody form   culture supernatant
antibody product type   primary antibodies
clone   MRQ-42, monoclonal
description   For In Vitro Diagnostic Use in Select Regions (See Chart)
form   buffered aqueous solution
species reactivity   human
packaging   vial of 0.1 mL concentrate (156R-94)
  vial of 0.5 mL concentrate (156R-95)
  bottle of 1.0 mL predilute (156R-97)
  vial of 1.0 mL concentrate (156R-96)
  bottle of 7.0 mL predilute (156R-98)
mfr. no.   Cell Marque
concentration   0.1-1 μg/mL (predilute)
  10-100 μg/mL (concentrate)
application(s)   immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
isotype   IgG1
conjugate   unconjugated
control   neuroblastoma
shipped in   wet ice
storage temp.   2-8°C
visualization   membranous

Description

General description

CD56, known as neural cell adhesion molecule (NCAM), was originally identified in the nervous system and belongs to a group of cell adhesion molecules including cadherins, selectins, and integrins. Anti-CD56 recognizes two proteins of the NCAM, the basic molecule expressed on most neuroectodermally-derived cell lines, tissues and neoplasms (e.g. neuroblastomas, small cell carcinomas). It is also expressed on some mesodermally-derived tumors (rhabdomyosarcoma). Furthermore, anti-CD56 has found great utility in the recognition of NK cell and NK/Tcell lymphomas. It has been shown that 71% of myelomas are positive for anti-CD56 as well. It also offers higher sensitivity in the diagnosis of small cell carcinoma than anti-chromogranin and anti-synaptophysin. Light staining of smooth muscle elements may be seen.

Linkage

CD56 Positive Control Slides, Product No. 156S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Preparation Note

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Quality


IVD

IVD

IVD

RUO

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

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Peer-Reviewed Papers
15

References

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156S CD56 Positive Control Slides, immunohistochemistry (formalin-fixed, paraffin-embedded sections) 

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