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157M-9 Sigma-Aldrich

CD57 (NK-1) Mouse Monoclonal Antibody

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Properties

Related Categories Alphabetical Index, Antibodies, CD0-CDC, Cell Marque Antibodies, Hematopathology,
Quality Level   GMP-IVD
biological source   mouse
antibody form   diluted ascites fluid
antibody product type   primary antibodies
clone   NK-1, monoclonal
description   For In Vitro Diagnostic Use in Select Regions (See Chart)
form   buffered aqueous solution
species reactivity   human
packaging   vial of 0.1 mL concentrate (157M-94)
  vial of 0.5 mL concentrate (157M-95)
  bottle of 1.0 mL predilute (157M-97)
  vial of 1.0 mL concentrate (157M-96)
  bottle of 7.0 mL predilute (157M-98)
mfr. no.   Cell Marque
concentration   0.01-1 μg/mL (predilute)
  0.5-50 μg/mL (concentrate)
application(s)   immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
isotype   IgMκ
conjugate   unconjugated
control   tonsil
shipped in   wet ice
storage temp.   2-8°C
visualization   membranous

Description

General description

CD57 is a marker expressed in the membrane of NK cells and other T cells. It is often used in the identification of nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) to visualize the small T-cells that ring the LP cells (rosettes of follicular T cells around the large neoplastic LP cells). These features can be used to distinguish NLPHL from T-cell/histiocyte-rich large B-cell lymphoma, which usually shows no rosettes of CD57-positive follicular T-cells around the large tumor cells. Anti-CD57 also reacts with neuroendocrine cells and their derived tumors, including neuroendocrine tumors of diverse origins, pheochromocytomas, paragangliomas, medulloblastoma, and varying proportions of neural tumors such as schwannomas, neurofibromas, neuromas, and granular cell tumors. However, anti-CD57 lacks the specificity of chromogranin and synaptophysin for detecting neuroendocrine neoplasms and therefore should be considered in a panel. Anti-CD57 can also be useful in separating thymoma from thymic carcinoma when combined with a panel that includes antibodies against CD5 and CD117.

Linkage

CD57 Positive Control Slides, Product No. 157S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Preparation Note

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Quality


IVD

IVD

IVD

RUO

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

Protocols & Articles

Articles

Antibody Basics

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M.D. Pathologist and Chief Medical Officer
Keywords: Adhesion, Cancer, Clinical, Diagnostic, Gastrointestinal, Gene expression, Genetics, Growth factors, Hormones, Immunohistochemistry, Immunostaining, Indicators, Microscopy, Morphogenesis, Obesity, Transcription

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Peer-Reviewed Papers
15

References

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157S CD57 Positive Control Slides, immunohistochemistry (formalin-fixed, paraffin-embedded sections) 

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