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157M-9 Sigma-Aldrich

CD57 (NK-1) Mouse Monoclonal Antibody



Related Categories Alphabetical Index, Antibodies, CD0-CDC, Cell Marque Antibodies, Hematopathology,
Quality Level   GMP-IVD
biological source   mouse
antibody form   diluted ascites fluid
antibody product type   primary antibodies
clone   NK-1, monoclonal
description   For In Vitro Diagnostic Use in Select Regions (See Chart)
form   buffered aqueous solution
species reactivity   human
packaging   vial of 0.1 mL concentrate (157M-94)
  vial of 0.5 mL concentrate (157M-95)
  bottle of 1.0 mL predilute (157M-97)
  vial of 1.0 mL concentrate (157M-96)
  bottle of 7.0 mL predilute (157M-98)
mfr. no.   Cell Marque
concentration   0.01-1 μg/mL (predilute)
  0.5-50 μg/mL (concentrate)
application(s)   immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
isotype   IgMκ
conjugate   unconjugated
control   tonsil
shipped in   wet ice
storage temp.   2-8°C
visualization   membranous


General description

CD57 is a marker expressed in the membrane of NK cells and other T cells. It is often used in the identification of nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) to visualize the small T-cells that ring the LP cells (rosettes of follicular T cells around the large neoplastic LP cells). These features can be used to distinguish NLPHL from T-cell/histiocyte-rich large B-cell lymphoma, which usually shows no rosettes of CD57-positive follicular T-cells around the large tumor cells. Anti-CD57 also reacts with neuroendocrine cells and their derived tumors, including neuroendocrine tumors of diverse origins, pheochromocytomas, paragangliomas, medulloblastoma, and varying proportions of neural tumors such as schwannomas, neurofibromas, neuromas, and granular cell tumors. However, anti-CD57 lacks the specificity of chromogranin and synaptophysin for detecting neuroendocrine neoplasms and therefore should be considered in a panel. Anti-CD57 can also be useful in separating thymoma from thymic carcinoma when combined with a panel that includes antibodies against CD5 and CD117.


CD57 Positive Control Slides, Product No. 157S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Other Notes

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Preparation Note

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Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

NONH for all modes of transport


Certificate of Analysis

Protocols & Articles


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157S CD57 Positive Control Slides, immunohistochemistry (formalin-fixed, paraffin-embedded sections) 

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