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15862 Sigma-Aldrich

Cobalt chloride 0.1 M solution

Synonym: Additive Screening Solution 24/Kit-No 78374, Cobalt(II)-chloride solution

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Properties

InChI Key   GVPFVAHMJGGAJG-UHFFFAOYSA-L
density   1.01 g/mL at 20 °C
storage temp.   2-8°C

Description

Application

Cobalt chloride 0.1M solution has been used to simulate hypoxic exposure and HIF-1 (hypoxia-inducible factor 1) expression in prostate cancer cells. It has been used to induce hypoxia in human intestinal epithelial cells.

Biochem/physiol Actions

Cobalt chloride induces hypoxia condition in cells by upregulating hypoxia-inducible factor-1α (HIF-1α), erythropoietin and glycolytic enzymes. It is also responsible for mitochondrial DNA damage in rat neuronal PC12 cells. It is also responsible for the induction of apoptosis.
Cobalt chloride 0.1M solution is an additive screening solution of Additive Screening Kit. Additive Screen kit is designed to allow rapid and convenient evaluation of additives and their ability to influence the crystallization of the sample. The Additive Kit provides a tool for refining crystallization conditions.

Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Danger
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Protocols & Articles
Peer-Reviewed Papers
15

References

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