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164602K Sigma-Aldrich

MAPTRIX-L-RNIAEIIKDI

Laminin Mimetic, aqueous solution

  •  NACRES NA.75

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Properties

Related Categories Cell Culture, ECM Mimetic Reagents, Laminin Mimetic, Reagents and Supplements
sterility   Filtered sterilized solution
form   aqueous solution
mol wt   ~23.8 kDa
packaging   pkg of 2.5 mg
concentration   0.5 mg/mL protein
application(s)   cell culture | mammalian: suitable
Binding Specificity   Domain: γ1 chain
Binding Motif: RNIAEIIKDI
shipped in   ambient
storage temp.   2-8°C

Description

Application

MAPTrix Technology provides a true extracellular microenvironment (ECM) by presenting combinatorial peptide motifs. The ECM, defined by biochemical cues and physical cues, is a deciding factor in a wide range of cellular processes including cell adhesion, proliferation, differentiation, and expression of phenotype-specific functions.Currently existing technology offers simple and merely adequate environments that facilitate simple cell processes such as cellular adhesion. The simple presentation of cell adhesion motifs is not optimal for controlling more integrated processes. Crosstalk among signaling pathways act synergistically to enhance cellular responses such as cell adhesion or proliferation. A study showed that a combination of extracellular matrix derived peptides presented on a surface may enhance cell adhesion strength and focal adhesion assembly. The combinatorial presentation of ECM peptides on cell growth surfaces may also promote elevated proliferation rates of primary or stem cells.

Features and Benefits

• Biochemically-defined, animal-free cell culture surfaces designed to enhance cell performance
• MAPTrix produces a uniform ECM surface that provides a highly controlled 2D extracellular microenvironment for cell cultures and related applications
• Adhesion properties of the mussel adhesive protein makes the coating reproducible & reliable

Legal Information

MAPTrix is a trademark of Kollodis Biosciences

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

An ECM Mimetic Library for Engineering Surfaces to Direct Cell Surface Receptor Binding Specificity and Signaling

The extracellular (ECM) microenvironment, defined by biochemical cues and physical cues, is a deciding factor in a wide range of cellular processes including cell adhesion, proliferation, differentia...
Keywords: Adhesion, Angiogenesis, Antitumor agents, Cell attachment, Cell culture, Cell signaling, Cellular processes, Gene expression, Ligands, Rearrangements

Extracellular Matrix Proteins and tools for cell culture optimization

Animal cells and tissue culture techniques are constantly improved to optimize in vitro cell culture conditions. Extracellular Matrix (ECM) proteins coating, chemical or physical modification of the ...
Keywords: Adhesion, Angiogenesis, Apoptosis, Asymmetric synthesis, Cancer, Cell attachment, Cell culture, Cell proliferation, Coagulation, Endocrinology, Growth factors, Hormones

Related Content

Cell Culture Troubleshooting Guide

Cell culture has become one of the most fundamental techniques for modeling biological systems, and is of increasing importance in the biotechnology and pharmaceutical sectors as well as an essential...
Keywords: Antibiotics, Apoptosis, Cell attachment, Cell culture, Cryopreservation, Filtration, Growth factors, Pharmaceutical, Phase transitions

Peer-Reviewed Papers
15

References

Related Products

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