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17936 Sigma-Aldrich

1α,25-Dihydroxyvitamin D3

≥97.0% (HPLC)

Synonym: 1α,25-Dihydroxycholecalciferol, Calcitriol

  • CAS Number 32222-06-3

  • Empirical Formula (Hill Notation) C27H44O3

  • Molecular Weight 416.64

  •  Beilstein/REAXYS Number 7559394

  •  EC Number 250-963-8

  •  MDL number MFCD00867079

  •  eCl@ss 34058003

  •  PubChem Substance ID 57647688

  •  NACRES NA.79

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Properties

Related Categories Biochemicals and Reagents, Cell Biology, Metabolic Pathways, Metabolomics, Steroid Metabolism,
Quality Level   200
assay   ≥97.0% (HPLC)
form   crystals
color   white to off-white
storage temp.   −70°C
SMILES string   [H][C@@]1(CC[C@@]2([H])C(\CCC[C@]12C)=C\C=C3\C[C@@H](O)C[C@H](O)C3=C)[C@H](C)CCCC(C)(C)O
InChI   1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25+,27-/m1/s1
InChI key   GMRQFYUYWCNGIN-NKMMMXOESA-N
Gene Information   human ... VDR(7421)

Description

General description

1α,25-Dihydroxyvitamin D3, also referred as calcitriol, is a calcitrophic hormone. It is the most biologically active metabolite of vitamin D produced in proximal tubular cells in the kidney.

Application

1α,25-Dihydroxyvitamin D3 has been used to study its effect on transplantation success of human muscle precursor cells (hMPCs) in severe combined immunodeficient (SCID) mice in-vitro.

Packaging

1 mg in poly bottle

100 μg in poly bottle

Biochem/physiol Actions

1α,25-Dihydroxyvitamin D3 modulates energy metabolism by facilitating various metabolic processes, such as Ca2+ signaling and modulation of glucocorticoids, by affecting adipocyte apoptosis and by regulating the expression and production of multiple cytokines. In addition, it also modulates phosphorus homeostasis through actions in the intestine, kidney and bone. 1α,25-Dihydroxyvitamin D3 exhibits antiproliferative effects and is used as a potent therapeutic for human prostate cancer.

Biologically active form of vitamin D3 in calcium absorption and deposition. 1α,25-Dihydroxyvitamin D3 has widespread effects on cellular differentiation and proliferation, and can modulate immune responsiveness, and central nervous system function. Recent studies suggest that 1α,25-dihydroxyvitamin D3 acts as a chemopreventive agent against several malignancies including cancers of the prostate and colon and shows synergy with other anticancer compounds.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN 2811 6.1 / PGI
WGK Germany 
WGK 2
RTECS 
FZ4645000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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