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17946 Sigma-Aldrich

1α-Hydroxyvitamin D3

≥97.0% (HPLC)

Synonym: 1α-Hydroxycholecalciferol, Alfacalcidol

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Properties

Related Categories Biochemicals and Reagents, Cell Biology, Metabolic Pathways, Metabolomics, Steroid Metabolism,
Quality Level   100
biological source   synthetic
assay   ≥97.0% (HPLC)
form   powder or crystals
color   white to off-white
storage temp.   −20°C
SMILES string   CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C3\C[C@@H](O)C[C@H](O)C3=C
InChI   1S/C27H44O2/c1-18(2)8-6-9-19(3)24-13-14-25-21(10-7-15-27(24,25)5)11-12-22-16-23(28)17-26(29)20(22)4/h11-12,18-19,23-26,28-29H,4,6-10,13-17H2,1-3,5H3/b21-11+,22-12-/t19-,23-,24-,25+,26+,27-/m1/s1
InChI key   OFHCOWSQAMBJIW-AVJTYSNKSA-N
Gene Information   human ... VDR(7421)

Description

General description

1α-Hydroxyvitamin D3, also known as alfacalcidol, is a synthetic vitamin D3 analogue, hydroxylated in position one. It is metabolized to 1,25-dihydroxycholecalciferol by 25-hydroxylases.

Biochem/physiol Actions

1α-Hydroxyvitamin D3 facilitates calcium absorption and deposition. It also has an ability to inhibit bone resorption and stimulate bone formation. Alfacalcidol is used for treating various bone diseases such as rickets/osteomalacia, renal osteodystrophy and osteoporosis. It acts as a chemopreventive agent and reduces the risk colitis and carcinogenesis.

Synthetic vitamin D3 analog that is metabolized to 1,25-dihydroxycholecalciferol. Inhibits bone resorption and stimulates bone formation. Supresses parathyroid hormone secretion by bovine parathyroid cells.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGI
WGK Germany 
WGK 3
RTECS 
VS2851000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

LC-MS Analysis of Vitamin D Metabolite Critical Pairs in Serum

The unique combination of column selectivity using Ascentis® Express F5 and phospholipid removal using HybridSPE®-PLus provides a robust and accurate LC-MS method for accurate and sensitive analysis ...
Craig Aurand, Strategic Marketing Team Manager, Integrated Sample Preparation and Hugh Cramer, Scientist, Advanced Sample Preparation Technologies
Keywords: Buffers, Enzyme-linked immunosorbent assay, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Metabolites, Phase transitions, Precipitation, Reductions, Sample preparations, Separation, Solvents, Vitamins

LC/MS/MS Analysis of Vitamin D Metabolites on Ascentis® Express F5 (Monitored Ions)

From our library of Articles, Sigma-Aldrich presents LC/MS/MS Analysis of Vitamin D Metabolites on Ascentis® Express F5 (Monitored Ions)
Keywords: Chromatography, Clinical, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Solvents, Vitamins

LC/MS/MS Analysis of Vitamin D Metabolites on Ascentis® Express F5

From our library of Articles, Sigma-Aldrich presents LC/MS/MS Analysis of Vitamin D Metabolites on Ascentis® Express F5
Keywords: Chromatography, Clinical, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Metabolites, Solvents, Vitamins

Method Optimization for LC-MS Analysis of Vitamin D Metabolite Critical Pairs in Serum

The unique combination of column selectivity using Ascentis Express F5 and phospholipid removal using HybridSPE-PLus provides a robust and accurate LC-MS method for accurate and sensitive analysis of...
Craig Aurand, Hugh Cramer
Reporter US Volume 32.1
Keywords: Buffers, Enzyme-linked immunosorbent assay, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Metabolites, Phase transitions, Precipitation, Reductions, Sample preparations, Separation, Solvents, Vitamins

Peer-Reviewed Papers
15

References

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