• USA Home
  • 200R-1 - Androgen Receptor (SP107) Rabbit Monoclonal Antibody

EMAIL THIS PAGE TO A FRIEND
200R-1 Sigma-Aldrich

Androgen Receptor (SP107) Rabbit Monoclonal Antibody

  •  NACRES NA.41

Purchase

Properties

Related Categories AM-AN, Alphabetical Index, Anatomic Pathology, Antibodies, Cell Marque Antibodies,
conjugate   unconjugated
clone   SP107, monoclonal
biological source   rabbit
application(s)   immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200
species reactivity   human
form   buffered aqueous solution
shipped in   wet ice
storage temp.   2-8°C
packaging   vial of 0.1 mL concentrate (200R-14)
  vial of 0.5 mL concentrate (200R-15)
  bottle of 1.0 mL predilute (200R-17)
  vial of 1.0 mL concentrate (200R-16)
  bottle of 7.0 mL predilute (200R-18)
antibody form   culture supernatant
isotype   IgG
Quality Level   100
  500
antibody product type   primary antibodies
description   For In Vitro Diagnostic Use in Select Regions (See Chart)
mfr. no.   Cell Marque
concentration   0.5-5.0 μg/mL (predilute)
  25-250 μg/mL (concentrate)
control   prostate
visualization   nuclear

Description

General description

Qualitative and quantitative alterations of androgen receptor expression in prostatic carcinomas and their possible implications for tumor progression and treatment are therefore of diagnostic and research interest. Findings in prostatic tumor cell lines of rat and human origin suggest that reduction of androgen receptor protein expression is accompanied by an increase in tumor aggressiveness. However, immunohistochemical analysis and binding assays have demonstrated the presence of androgen receptors in all histological types of prostatic carcinoma and in both therapy-responsive as well as therapy-unresponsive tumors. Most of the immunohistochemical studies of androgen receptors have been related to prostatic carcinoma and experimental animals. Patients with 48% or more androgen receptor-positive cells had statistically significant better outcome in terms of both progression-free and cause-specific survival. Another study suggested that prior to therapy, androgen receptor expression alone is not related to prognosis of hormonally treated prostate cancer; however, when combined with bcl-2 expression, it acts as an independent prognostic factor for clinical progression. The variability of androgen receptor protein content per unit nuclear area has been shown to increase with increasing histological grade, suggesting that this variability might account for the response to endocrine therapy in high grade tumors. The extent of heterogeneity of androgen receptor expression may be a useful indicator of response to hormonal therapy.

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC

Quality


IVD

IVD

IVD

RUO

Linkage

Androgen Receptor Positive Control Slides, Product No. 200S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Preparation Note

Download the IFU specific to your product lot and format
Note: This requires a keycode which can be found on your packaging or product label.

Download the latest released IFU
Note: This IFU may not apply to your specific product lot.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

Immunohistochemistry: Current Applications in Skin Cancer

Cutaneous Spindle Cell Tumors Cutaneous Adnexal Neoplasms Melanocytic Neoplasms Malignant Small Blue Cell Tumors Fibrohistiocytic Lesions Vascular Neoplasms Hematopoietic and Hystiocytic Tumors Infec...
Mike Lacey
M.D. Pathologist and Chief Medical Officer
Keywords: AGE, Addition reactions, Adhesion, Cancer, Cell biology, Clinical, Condensations, Diagnostic, Diseases, Gastrointestinal, Gene expression, Genetic, Growth factors, Immunohistochemistry, Immunostaining, Indicators, Infectious Diseases, Inflammation, Microarray Analysis, Microscopy, Polymerase chain reaction, Techniques and applications, Tissue microarrays, Transcription

Related Content

Antibody Explorer | Buy Primary Antibodies & Secondary Antibodies

Primary, Secondary and Recombinant Monoclonal Antibodies Providing highly cited primary and secondary antibodies, we have you covered for your ELISA, western blot, immunohistochemistry or other assay...
Keywords: Alzheimer Disease, Cancer, Chromatin immunoprecipitation, Diagnostic, Enzyme-linked immunosorbent assay, Flow cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Neuroscience, Western blot

Peer-Reviewed Papers
15

References

Related Products

control

Product #

Description

Add to Cart

200S Androgen Receptor Positive Control Slides, suitable for immunohistochemistry (formalin-fixed, paraffin-embedded sections) 

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?