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  • 200R-1 - Androgen Receptor (SP107) Rabbit Monoclonal Antibody

200R-1 Sigma-Aldrich

Androgen Receptor (SP107) Rabbit Monoclonal Antibody

  •  NACRES NA.41



Related Categories AM-AN, Alphabetical Index, Anatomic Pathology, Antibodies, Cell Marque Antibodies,
conjugate   unconjugated
clone   SP107, monoclonal
biological source   rabbit
application(s)   immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200
species reactivity   human
form   buffered aqueous solution
shipped in   wet ice
storage temp.   2-8°C
packaging   vial of 0.1 mL concentrate (200R-14)
  vial of 0.5 mL concentrate (200R-15)
  bottle of 1.0 mL predilute (200R-17)
  vial of 1.0 mL concentrate (200R-16)
  bottle of 7.0 mL predilute (200R-18)
antibody form   culture supernatant
isotype   IgG
Quality Level   100
antibody product type   primary antibodies
description   For In Vitro Diagnostic Use in Select Regions (See Chart)
mfr. no.   Cell Marque
concentration   0.5-5.0 μg/mL (predilute)
  25-250 μg/mL (concentrate)
control   prostate
visualization   nuclear


General description

Qualitative and quantitative alterations of androgen receptor expression in prostatic carcinomas and their possible implications for tumor progression and treatment are therefore of diagnostic and research interest. Findings in prostatic tumor cell lines of rat and human origin suggest that reduction of androgen receptor protein expression is accompanied by an increase in tumor aggressiveness. However, immunohistochemical analysis and binding assays have demonstrated the presence of androgen receptors in all histological types of prostatic carcinoma and in both therapy-responsive as well as therapy-unresponsive tumors. Most of the immunohistochemical studies of androgen receptors have been related to prostatic carcinoma and experimental animals. Patients with 48% or more androgen receptor-positive cells had statistically significant better outcome in terms of both progression-free and cause-specific survival. Another study suggested that prior to therapy, androgen receptor expression alone is not related to prognosis of hormonally treated prostate cancer; however, when combined with bcl-2 expression, it acts as an independent prognostic factor for clinical progression. The variability of androgen receptor protein content per unit nuclear area has been shown to increase with increasing histological grade, suggesting that this variability might account for the response to endocrine therapy in high grade tumors. The extent of heterogeneity of androgen receptor expression may be a useful indicator of response to hormonal therapy.

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC







Androgen Receptor Positive Control Slides, Product No. 200S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Preparation Note

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Other Notes

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Safety & Documentation

Safety Information

NONH for all modes of transport


Certificate of Analysis (COA)

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Protocols & Articles


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200S Androgen Receptor Positive Control Slides, suitable for immunohistochemistry (formalin-fixed, paraffin-embedded sections) 

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